PMID- 25656764
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20211203
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 107
IP  - 3
DP  - 2015 Mar
TI  - Does Strongyloides stercoralis infection protect against type 2 diabetes in 
      humans? Evidence from Australian Aboriginal adults.
PG  - 355-61
LID - S0168-8227(15)00020-0 [pii]
LID - 10.1016/j.diabres.2015.01.012 [doi]
AB  - OBJECTIVE: To explore the relationship between infection with Strongyloides 
      stercoralis and the likelihood of having type 2 diabetes mellitus (T2DM). 
      METHODS: Cross-sectional survey of 259 Aboriginal adults living in a remote 
      community in northern Australia during 2013. Prior infection with S. stercoralis 
      was determined by ELISA testing on serum. Main outcomes were eosinophil count, 
      T2DM diagnosis, HbA1c, BMI, fasting lipids, Hb, blood pressure. FINDINGS: Ninety 
      two participants (36%) had prior infection with S. stercoralis and 131 (51%) had 
      T2DM. Those with previous S. stercoralis infection (ELISA titre >/=0.3) were 61% 
      less likely to have a diagnosis of T2DM than those uninfected, adjusted for age, 
      triglycerides, blood pressure and BMI using propensity score (adjusted OR=0.39, 
      0.23-0.67, P=0.001). INTERPRETATION: In this remote community where prevalence of 
      both S. stercoralis and T2DM is very high, infection with S. stercoralis appears 
      to be associated with a significantly reduced risk of T2DM in adults. A plausible 
      immunological mechanism has been identified in animal models. If confirmed, this 
      result may have practical implications for the prevention of T2DM and associated 
      metabolic disorders in humans. This finding should be explored further with 
      larger longitudinal studies in transitional populations where the risk of both 
      conditions is high. FUNDING: No external funding was required for this study.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Hays, Russell
AU  - Hays R
AD  - Kimberley Aboriginal Medical Services Council, PO Box 1377, Broome 6725, WA, 
      Australia; Adjunct Research Fellow James Cook University, James Cook University, 
      Cairns Campus, McGregor Road, Smithfield 4878, QLD, Australia. Electronic 
      address: rhays@ozcom.au.
FAU - Esterman, Adrian
AU  - Esterman A
AD  - Centre for Research Excellence in Chronic Disease Prevention, The Cairns 
      Institute James Cook University, Cairns Campus, Room D3-131, McGregor Road, 
      Smithfield 4878, QLD, Australia; Chair of Biostatistics, Sansom Institute of 
      Health Service Research and School of Nursing and Midwifery, University of South 
      Australia City East Campus, Centenary Building, North Terrace, Adelaide 5000, SA, 
      Australia.
FAU - Giacomin, Paul
AU  - Giacomin P
AD  - Centre for Biodiscovery and Molecular Development of Therapeutics, Australian 
      Institute of Tropical Health and Medicine, James Cook University, Cairns Campus, 
      McGregor Road, Smithfield 4878, QLD, Australia.
FAU - Loukas, Alex
AU  - Loukas A
AD  - Centre for Biodiscovery and Molecular Development of Therapeutics, Australian 
      Institute of Tropical Health and Medicine, James Cook University, Cairns Campus, 
      McGregor Road, Smithfield 4878, QLD, Australia.
FAU - McDermott, Robyn
AU  - McDermott R
AD  - Public Health Medicine, Centre for Chronic Disease Prevention, Australian 
      Institute of Tropical Health and Medicine, College of Public Health, Medical and 
      Veterinary Sciences, James Cook University, PO Box 6811, Cairns 4870, QLD, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20150121
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Adult
MH  - Animals
MH  - Australia/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/*epidemiology/physiopathology
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Native Hawaiian or Other Pacific Islander/*statistics & numerical data
MH  - Prevalence
MH  - Strongyloides stercoralis/*physiology
MH  - Strongyloidiasis/blood/complications/*epidemiology/physiopathology
OTO - NOTNLM
OT  - Helminth infection
OT  - Immunomodulation
OT  - Strongyloides stercoralis
OT  - Type 2 diabetes mellitus
EDAT- 2015/02/07 06:00
MHDA- 2015/09/15 06:00
CRDT- 2015/02/07 06:00
PHST- 2014/10/11 00:00 [received]
PHST- 2014/11/06 00:00 [revised]
PHST- 2015/01/03 00:00 [accepted]
PHST- 2015/02/07 06:00 [entrez]
PHST- 2015/02/07 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - S0168-8227(15)00020-0 [pii]
AID - 10.1016/j.diabres.2015.01.012 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2015 Mar;107(3):355-61. doi: 
      10.1016/j.diabres.2015.01.012. Epub 2015 Jan 21.