PMID- 25657859
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150206
LR  - 20200930
IS  - 2229-5097 (Print)
IS  - 2152-7806 (Electronic)
IS  - 2152-7806 (Linking)
VI  - 6
DP  - 2015
TI  - Neurosurgery concepts: Key perspectives on dendritic cell vaccines, metastatic 
      tumor treatment, and radiosurgery.
PG  - 6
LID - 10.4103/2152-7806.149389 [doi]
LID - 6
AB  - BACKGROUND: This is a laboratory study to investigate the effect of adding 
      brain-derived-neurotrophic factor (BDNF) in a poly (N-isopropylacrylamide-g-poly 
      (ethylene glycol) scaffold and its effect on spinal cord injury in a rat model. 
      METHODS: This is a laboratory investigation of a spinal cord injury in a rat 
      model. A dorsolateral funiculotomy was used to disrupt the dorsolateral funiculus 
      and rubrospinal tract. Animals were then injected with either the scaffold 
      polymer or scaffold polymer with BDNF. Postoperatively, motor functions were 
      assessed with single pellet reach to grasp task, stair case reaching task and 
      cylinder task. Histological study was also performed to look at extent of glial 
      scar and axonal growth. RESULTS: Animals received BDNF containing polymer had an 
      increased recovery rate of fine motor function of forelimb, as assessed by stair 
      case reaching task and single pellet reach to grasp task compared with control 
      animals that received the polymer only. There is no significant difference in the 
      glial scar formation. BDNF treated animals also had increased axon growth 
      including increase in the number and length of the rubrospinal tract axons. 
      CONCLUSION: BDNF delivered via a scaffold polymer results in increased recovery 
      rate in forelimb motor function in an experimental model of spinal cord injury, 
      possibly through a promotion of growth of axons of the rubrospinal tract.
FAU - Li, Gordon
AU  - Li G
AD  - Department of Neurosurgery, Stanford School of Medicine, Washington DC, USA.
FAU - Sherman, Jonathan H
AU  - Sherman JH
AD  - Department of Neurosurgery, George Washington University, Washington DC, USA.
FAU - Cho, Jin Mo
AU  - Cho JM
AD  - Department of Neurosurgery, Ajou University School of Medicine, Gyeonggi-do, 
      South Korea.
FAU - Lim, Michael
AU  - Lim M
AD  - Department of Neurosurgery, Johns Hopkins School of Medicine, Maryland, USA.
FAU - Khalessi, Alexander A
AU  - Khalessi AA
AD  - Department of Neurosurgery, University of California San Diego, CA, USA.
FAU - Colen, Chaim B
AU  - Colen CB
AD  - Department of Neurosurgery, Beaumont Hospital, Grosse Pointe, MI, USA.
FAU - Kim, Chae Yong
AU  - Kim CY
AD  - Department of Neurosurgery, Seoul National University College of Medicine, Seoul, 
      South Korea.
FAU - Wang, Vincent Yat
AU  - Wang VY
AD  - Department of Neurosurgery, University of California San Francisco, CA, USA.
FAU - Zada, Gabriel
AU  - Zada G
AD  - Department of Neurosurgery, Keck School of Medicine at University of Southern 
      California, CA, US.
FAU - Smith, Zachary A
AU  - Smith ZA
AD  - Department of Neurosurgery, Northwestern Feinberg School of Medicine, IL, US.
FAU - Yang, Isaac
AU  - Yang I
AD  - Department of Neurosurgery, David Geffen School of Medicine at University of 
      California Los Angeles, CA, US.
LA  - eng
PT  - Journal Article
DEP - 20150114
PL  - United States
TA  - Surg Neurol Int
JT  - Surgical neurology international
JID - 101535836
PMC - PMC4310042
OTO - NOTNLM
OT  - Gamma Knife
OT  - Radiosurgery
OT  - dens fracture
OT  - glioblastoma
OT  - immunotherapy
OT  - meningiomas
OT  - metastasis
EDAT- 2015/02/07 06:00
MHDA- 2015/02/07 06:01
PMCR- 2015/01/14
CRDT- 2015/02/07 06:00
PHST- 2014/06/30 00:00 [received]
PHST- 2014/07/02 00:00 [accepted]
PHST- 2015/02/07 06:00 [entrez]
PHST- 2015/02/07 06:00 [pubmed]
PHST- 2015/02/07 06:01 [medline]
PHST- 2015/01/14 00:00 [pmc-release]
AID - SNI-6-6 [pii]
AID - 10.4103/2152-7806.149389 [doi]
PST - epublish
SO  - Surg Neurol Int. 2015 Jan 14;6:6. doi: 10.4103/2152-7806.149389. eCollection 
      2015.