PMID- 2565796
OWN - NLM
STAT- MEDLINE
DCOM- 19890615
LR  - 20190824
IS  - 0300-9629 (Print)
IS  - 0300-9629 (Linking)
VI  - 92
IP  - 3
DP  - 1989
TI  - Biochemical correlates of the structural allometry and site-specific properties 
      of mammalian adipose tissue.
PG  - 455-63
AB  - 1. The maximum activities of the glycolytic enzymes hexokinase (HK) and 
      phosphofructokinase (PFK) were measured in defatted homogenates of adipose tissue 
      from nine homologous depots of 57 wild and captive mammals belonging to 17 
      species and eight orders and differing in body mass by six orders of magnitude. 
      2. Site-specific differences in the enzyme activities were similar in all 
      terrestrial species and were not consistently related to adipocyte volume. 3. The 
      specimen-mean maximum activities of HK and PFK did not correlate with body mass, 
      body composition or natural diet. 4. When specimens of different body composition 
      and body mass were compared, glycolytic enzyme activity per adipocyte was 
      directly proportional to adipocyte volume. 5. Site-specific differences in 
      collagen content of adipose tissue did not correspond to those adipocyte volume. 
      When homologous depots of different specimens were compared, the collagen content 
      of adipose tissue was directly proportional to body mass. 6. Adipose tissue of 
      large cetaceans contains more collagen than predicted from the allometric 
      equations fitted to the data from terrestrial mammals. 7. Neither the scaling of 
      the collagen content with body mass nor the site-specific differences in its 
      abundance are consistent with a role as protection or support for adjacent 
      tissues. 8. There are consistent site-specific differences in the extracellular 
      components of adipose tissue as well as in the structure and metabolism of the 
      adipocytes. 9. Adipose tissue differs from most other tissues in that its maximum 
      metabolic capacities do not scale to body mass. 10. Adjustment of the biochemical 
      activity of adipose tissue to changes in body mass and body composition must 
      depend upon neural and endocrine controls, not upon intrinsic differences in its 
      metabolic capabilities.
FAU - Pond, C M
AU  - Pond CM
AD  - Department of Biology, Open University, Milton Keynes, UK.
FAU - Mattacks, C A
AU  - Mattacks CA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Comp Biochem Physiol A Comp Physiol
JT  - Comparative biochemistry and physiology. A, Comparative physiology
JID - 1276312
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
SB  - IM
MH  - Adipose Tissue/cytology/*enzymology
MH  - Animals
MH  - Animals, Wild/*metabolism
MH  - Animals, Zoo/*metabolism
MH  - Hexokinase/*metabolism
MH  - Mammals/*metabolism
MH  - Phosphofructokinase-1/*metabolism
MH  - Species Specificity
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1016/0300-9629(89)90591-4 [doi]
PST - ppublish
SO  - Comp Biochem Physiol A Comp Physiol. 1989;92(3):455-63. doi: 
      10.1016/0300-9629(89)90591-4.