PMID- 25658150
OWN - NLM
STAT- MEDLINE
DCOM- 20160411
LR  - 20150224
IS  - 1651-2006 (Electronic)
IS  - 1401-7431 (Linking)
VI  - 49
IP  - 1
DP  - 2015 Feb
TI  - Impact of chronic obstructive pulmonary disease on survival and symptoms of 
      severe aortic valve stenosis.
PG  - 49-55
LID - 10.3109/14017431.2015.1006671 [doi]
AB  - BACKGROUND: As patients with severe aortic valve stenosis (AS) develop symptoms 
      their survival decreases rapidly, if treated conservatively. Transcatheter aortic 
      valve implantation (TAVI) has been introduced as a less invasive treatment 
      alternative, especially in inoperable patients, who often have severe 
      comorbidities, including chronic obstructive pulmonary disease (COPD). MATERIALS 
      AND METHODS: Since the beginning of our TAVI program in March 2008, data on all 
      131 TAVI patients were prospectively and consecutively collected in this registry 
      with complete follow-up. COPD was present in 37 patients. By January 2012 
      survival data were collected from the Danish Civil Registration System. Median 
      follow-up duration was 559 days. RESULTS: Overall survival and survival from 
      cardiac death was equivalent in both patients with and without COPD (p = 0.98 and 
      p = 0.26) in the follow-up period. Further, patients with COPD had higher New 
      York Heart Association (NYHA) class prior to intervention compared with those 
      without (3.1 +/- 0.5 vs. 2.9 +/- 0.5, p = 0.02). In multivariate regression analysis 
      COPD was associated with 30-day postoperative NYHA class (0.43; 95% confidence 
      interval (CI): 0.10-0.75; p = 0.01), but not to NYHA class improvement from pre- 
      to postintervention (0.25; 95% CI: - 0.12 to -0.63; p = 0.18). CONCLUSIONS: In 
      patients with symptomatic severe AS treated with TAVI, the presence of COPD 
      neither affects overall survival nor survival from cardiac death. Patients with 
      COPD had, however, both higher pre- and postoperative NYHA class compared with 
      patients without COPD, but NYHA class improvement from pre- to postintervention 
      was equivalent in both groups.
FAU - Poulsen, Mikael K
AU  - Poulsen MK
AD  - Department of Cardiology, Odense University Hospital , Denmark.
FAU - Dahl, Jordi S
AU  - Dahl JS
FAU - Kjeldsen, Bo J
AU  - Kjeldsen BJ
FAU - Norregaard-Hansen, Knud
AU  - Norregaard-Hansen K
FAU - Pedersen, Knud Erik
AU  - Pedersen KE
FAU - Mickley, Hans
AU  - Mickley H
FAU - Nissen, Henrik
AU  - Nissen H
LA  - eng
PT  - Journal Article
DEP - 20150211
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/diagnosis/mortality/physiopathology/*therapy
MH  - *Cardiac Catheterization/adverse effects/methods/mortality
MH  - Comorbidity
MH  - Denmark/epidemiology
MH  - Female
MH  - *Heart Valve Prosthesis Implantation/adverse effects/methods/mortality
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic 
      Obstructive/diagnosis/*epidemiology/mortality/physiopathology
MH  - Recovery of Function
MH  - Registries
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - aortic valve stenosis
OT  - chronic obstructive pulmonary disease
OT  - transcatheter aortic valve implantation
EDAT- 2015/02/07 06:00
MHDA- 2016/04/12 06:00
CRDT- 2015/02/07 06:00
PHST- 2015/02/07 06:00 [entrez]
PHST- 2015/02/07 06:00 [pubmed]
PHST- 2016/04/12 06:00 [medline]
AID - 10.3109/14017431.2015.1006671 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2015 Feb;49(1):49-55. doi: 10.3109/14017431.2015.1006671. 
      Epub 2015 Feb 11.