PMID- 25658497 OWN - NLM STAT- MEDLINE DCOM- 20150826 LR - 20221207 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 175 DP - 2015 Apr 1 TI - Brain-derived neurotrophic factor Val66Met polymorphism and 6-month antidepressant remission in depressed Caucasian patients. PG - 233-40 LID - S0165-0327(15)00017-8 [pii] LID - 10.1016/j.jad.2015.01.013 [doi] AB - BACKGROUND: Whether the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphism can predict antidepressant drug efficacy in depressed patients remains unclear, suggesting that it may depend on antidepressant classes. We assessed the impact of Val66Met polymorphism on antidepressant response and remission depending on antidepressant classes. METHODS: In a 6-month prospective, real-world setting, treatment study, 345 Caucasian depressed patients requiring a new or different drug treatment with a selective serotonin reuptake inhibitor (SSRI), a serotonin and noradrenalin reuptake inhibitor (SNRI) or a tricyclic antidepressant (TCA), were genotyped and assessed for response and remission. RESULTS: 231 (67%) patients were homozygous for the Val66 allele (Val/Val) and 114 (33%) were carriers of Met allele (Met). 152 (44.1%) patients were treated with SSRI, the others with SNRI/TCA. Both response and remission were explained by interactions between the Val66Met polymorphism and antidepressant drug classes (multivariate models adjusted for propensity-scores: p=0.02 and p=0.03 respectively). With SSRI, Val/Val patients had a higher response rate 3 months post-treatment than Met patients (68.1% versus 44%; adjusted-OR: 3.04, IC95% [1.05; 9.37], p=0.04). With SNRI/TCA, Val/Val patients had a lower remission rate 6 months post-treatment than Met patients (33.3% versus 60.9%, adjusted-OR: 0.27, IC95% [0.09; 0.76], p=0.02). LIMITATIONS: Limited sample size. CONCLUSIONS: This study argues for a personalized prescription of antidepressants in Caucasian patients with major depressive disorder, based on the BDNF Val66Met polymorphism: SSRI should be preferred for Val/Val patients and SNRI/TCA for Met patients. Further studies are required to confirm these data. CI - Copyright (c) 2015 Elsevier B.V. All rights reserved. FAU - Colle, Romain AU - Colle R AD - INSERM U1178 Team <>, Faculte de Medecine Paris Sud, Service de Psychiatrie, Hopital Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France. Electronic address: romaincolle@hotmail.com. FAU - Gressier, Florence AU - Gressier F AD - INSERM U1178 Team <>, Faculte de Medecine Paris Sud, Service de Psychiatrie, Hopital Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France. FAU - Verstuyft, Celine AU - Verstuyft C AD - INSERM U1184 <> Univ Paris Sud, Service de Genetique moleculaire, Pharmacogenetique et Hormonologie, Hopital Bicetre, Assistance Publique-Hopitaux de Paris, Le Kremlin Bicetre F-94275, France; Univ Paris-Sud, INSERM U1184, 92296 Chatenay-Malabry Cedex, France. FAU - Deflesselle, Eric AU - Deflesselle E AD - INSERM U1178 Team <>, Faculte de Medecine Paris Sud, Service de Psychiatrie, Hopital Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France. FAU - Lepine, Jean-Pierre AU - Lepine JP AD - Universite Paris Diderot, Hopital Saint-Louis Lariboisiere Fernand Widal, Assistance Publique Hopitaux de Paris, INSERM UMR-S1144, 200 rue du Faubourg Saint Denis, F-75475 Paris Cedex 10, France. FAU - Ferreri, Florian AU - Ferreri F AD - UPMC Univ Paris 06, Service de Psychiatrie, Hopital Saint-Antoine, Assistance Publique Hopitaux de Paris, 184 rue du Faubourg Saint-Antoine, 75012 Paris, France. FAU - Hardy, Patrick AU - Hardy P AD - INSERM U1178 Team <>, Faculte de Medecine Paris Sud, Service de Psychiatrie, Hopital Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France. FAU - Guilloux, Jean-Philippe AU - Guilloux JP AD - INSERM U1178 Team <>, Faculte de Pharmacie Paris Sud, Chatenay-Malabry, France. FAU - Petit, Anne-Cecile AU - Petit AC AD - INSERM U1178 Team <>, Faculte de Medecine Paris Sud, Service de Psychiatrie, Hopital Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France. FAU - Feve, Bruno AU - Feve B AD - INSERM UMR S938, UPMC Univ Paris 06, Centre de Recherche Saint-Antoine, Hopital Saint-Antoine, Assistance Publique Hopitaux de Paris, 184 rue du Faubourg Saint-Antoine, F75012 Paris, France. FAU - Falissard, Bruno AU - Falissard B AD - INSERM UMR 1178, Faculte de Medecine Paris Sud, Departement de Biostatistiques, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, 94400 Villejuif, France. FAU - Becquemont, Laurent AU - Becquemont L AD - INSERM U1184 <> Univ Paris Sud, Service de Genetique moleculaire, Pharmacogenetique et Hormonologie, Hopital Bicetre, Assistance Publique-Hopitaux de Paris, Le Kremlin Bicetre F-94275, France; Univ Paris-Sud, INSERM U1184, 92296 Chatenay-Malabry Cedex, France. FAU - Corruble, Emmanuelle AU - Corruble E AD - INSERM U1178 Team <>, Faculte de Medecine Paris Sud, Service de Psychiatrie, Hopital Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France. LA - eng PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150121 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Alleles MH - Antidepressive Agents/adverse effects/*therapeutic use MH - Brain-Derived Neurotrophic Factor/*genetics MH - Depressive Disorder, Major/*drug therapy/*genetics MH - Female MH - Genotype MH - Heterozygote MH - Homozygote MH - Humans MH - Male MH - Middle Aged MH - Polymorphism, Single Nucleotide/genetics MH - Prospective Studies MH - *Remission Induction MH - White People/*genetics MH - Young Adult OTO - NOTNLM OT - Antidepressant OT - BDNF OT - Major depressive disorder OT - Remission OT - Response OT - Val66Met polymorphism EDAT- 2015/02/07 06:00 MHDA- 2015/08/27 06:00 CRDT- 2015/02/07 06:00 PHST- 2014/11/24 00:00 [received] PHST- 2015/01/09 00:00 [revised] PHST- 2015/01/12 00:00 [accepted] PHST- 2015/02/07 06:00 [entrez] PHST- 2015/02/07 06:00 [pubmed] PHST- 2015/08/27 06:00 [medline] AID - S0165-0327(15)00017-8 [pii] AID - 10.1016/j.jad.2015.01.013 [doi] PST - ppublish SO - J Affect Disord. 2015 Apr 1;175:233-40. doi: 10.1016/j.jad.2015.01.013. Epub 2015 Jan 21.