PMID- 25658731
OWN - NLM
STAT- MEDLINE
DCOM- 20150424
LR  - 20150209
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 31
IP  - 1
DP  - 2015 Jan
TI  - [IRIS: a paradoxical inflammatory reaction in patients treated simultaneously for 
      tuberculosis and HIV].
PG  - 53-9
LID - 10.1051/medsci/20153101013 [doi]
AB  - Co-infection with Mycobacterium tuberculosis (Mtb) and human immunodeficiency 
      virus (HIV) represents a major threat to public health worldwide. The treatment 
      of patients coinfected by Mtb and HIV is often complicated by the occurrence of 
      an immune reconstitution inflammatory syndrome (IRIS), resulting in the 
      unexpected resumption of tuberculosis symptoms after the initiation of 
      antiretroviral therapy. IRIS is associated with a rapid reconstitution of CD4(+) 
      T cell responses specific for Mtb, which is promoted by the control of HIV 
      replication and a high concentration of available interleukin-7. Macrophages, 
      whose activity is suddenly stimulated by CD4(+) T cell help, respond by an 
      exacerbated inflammatory response in Mtb-rich tissues. A major research objective 
      remains to identify biomarkers which could allow a reliable prediction of IRIS 
      occurrence, in order to optimize medical care for the many patients affected by 
      both HIV and tuberculosis in resource-limited settings.
CI  - (c) 2015 medecine/sciences - Inserm.
FAU - Chakrabarti, Lisa A
AU  - Chakrabarti LA
AD  - Unite de pathogenie virale, Inserm U1108, Institut Pasteur, 28, rue du Docteur 
      Roux, 75724 Paris Cedex 15, France.
FAU - Lortholary, Olivier
AU  - Lortholary O
AD  - Universite Paris Descartes, hopital Necker-Enfants malades, centre 
      d'infectiologie Necker Pasteur, IHU Imagine, AP-HP, Paris, France.
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - L'IRIS - Une reaction inflammatoire paradoxale chez les patients traites 
      simultanement pour une tuberculose et une infection par le VIH.
DEP - 20150206
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
MH  - Coinfection
MH  - HIV Infections/complications/immunology/*therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/diagnosis/*etiology/immunology
MH  - Inflammation/etiology/immunology
MH  - Risk Factors
MH  - Tuberculosis/complications/immunology/*therapy
EDAT- 2015/02/07 06:00
MHDA- 2015/04/25 06:00
CRDT- 2015/02/07 06:00
PHST- 2015/02/07 06:00 [entrez]
PHST- 2015/02/07 06:00 [pubmed]
PHST- 2015/04/25 06:00 [medline]
AID - medsci20153101p53 [pii]
AID - 10.1051/medsci/20153101013 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2015 Jan;31(1):53-9. doi: 10.1051/medsci/20153101013. Epub 2015 
      Feb 6.