PMID- 2565947
OWN - NLM
STAT- MEDLINE
DCOM- 19890615
LR  - 20190709
IS  - 0022-0795 (Print)
IS  - 0022-0795 (Linking)
VI  - 121
IP  - 1
DP  - 1989 Apr
TI  - Plasma concentrations of cholecystokinin octapeptide and food intake in male rats 
      treated with cholecystokinin octapeptide.
PG  - 59-65
AB  - Intraperitoneal injection of 5 micrograms cholecystokinin octapeptide (CCK-8) 
      into male rats deprived of food for 48 h produced a transient (less than 15 min) 
      increase in plasma levels of CCK-8 but suppressed food intake for an extended 
      period (45 min). Plasma concentrations of CCK-8 after i.p. injection of CCK-8 
      were raised to levels which were fairly comparable to those after feeding. 
      Intracerebroventricular (i.c.v.) injection of the CCK antagonist proglumide (100 
      micrograms) reversed the effect of CCK-8 on food intake, while i.p. injection of 
      proglumide (100 micrograms) did not have this effect. Feeding increased the 
      plasma concentrations of somatostatin and gastrin but not of oxytocin, and 
      somatostatin and oxytocin but not gastrin were released in response to i.p. 
      injection of CCK-8. However, neither somatostatin nor oxytocin affected food 
      intake, and their release in response to CCK-8 was unaffected by i.c.v. injection 
      of proglumide. These results support the suggestion that CCK-8 is a physiological 
      'satiety' peptide, which can affect food intake in rats by mechanisms involving 
      both peripheral and central CCK receptors.
FAU - Linden, A
AU  - Linden A
AD  - Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
FAU - Uvnas-Moberg, K
AU  - Uvnas-Moberg K
FAU - Forsberg, G
AU  - Forsberg G
FAU - Bednar, I
AU  - Bednar I
FAU - Sodersten, P
AU  - Sodersten P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Gastrins)
RN  - 50-56-6 (Oxytocin)
RN  - 51110-01-1 (Somatostatin)
RN  - EPL8W5565D (Proglumide)
RN  - M03GIQ7Z6P (Sincalide)
SB  - IM
MH  - Animals
MH  - Eating/*drug effects
MH  - Gastrins/blood
MH  - Male
MH  - Oxytocin/blood/pharmacology
MH  - Proglumide/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sincalide/blood/*pharmacology
MH  - Somatostatin/blood/pharmacology
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1677/joe.0.1210059 [doi]
PST - ppublish
SO  - J Endocrinol. 1989 Apr;121(1):59-65. doi: 10.1677/joe.0.1210059.