PMID- 25659937
OWN - NLM
STAT- MEDLINE
DCOM- 20150604
LR  - 20181113
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Print)
IS  - 0009-9260 (Linking)
VI  - 70
IP  - 5
DP  - 2015 May
TI  - Rest perfusion abnormalities in hypertrophic cardiomyopathy: correlation with 
      myocardial fibrosis and risk factors for sudden cardiac death.
PG  - 495-501
LID - S0009-9260(15)00022-7 [pii]
LID - 10.1016/j.crad.2014.12.018 [doi]
AB  - AIM: To measure the prevalence of abnormal rest perfusion in a population of 
      consecutive patients with known hypertrophic cardiomyopathy (HCM) referred for 
      cardiovascular MRI (CMR), and to assess any associations between abnormal rest 
      perfusion and the presence, pattern, and severity of myocardial scar and the 
      presence of risk factors for sudden death. MATERIALS AND METHODS: Eighty 
      consecutive patients with known HCM referred for CMR underwent functional 
      imaging, rest first-pass perfusion, and late gadolinium enhancement (LGE). 
      RESULTS: Thirty percent of the patients had abnormal rest perfusion, all of them 
      corresponding to areas of mid-myocardial LGE and to a higher degree of segmental 
      hypertrophy. Rest perfusion abnormalities correlated with more extensive and 
      confluent LGE. The subgroup of patients with myocardial fibrosis and rest 
      perfusion abnormalities (fibrosis+/perfusion+) had more than twice the incidence 
      of episodes of non-sustained ventricular tachycardia on Holter monitoring in 
      comparison to patients with myocardial fibrosis and normal rest perfusion 
      (fibrosis+/perfusion-) and patients with no fibrosis and normal rest perfusion 
      (fibrosis-/perfusion-). CONCLUSIONS: First-pass perfusion CMR identifies abnormal 
      rest perfusion in a significant proportion of patients with HCM. These 
      abnormalities are associated with the presence and distribution of myocardial 
      scar and the degree of hypertrophy. Rest perfusion abnormalities identify 
      patients with increased incidence of episodes of non-sustained ventricular 
      tachycardia on Holter monitoring, independently from the presence of myocardial 
      fibrosis.
CI  - Copyright (c) 2015 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Chiribiri, A
AU  - Chiribiri A
AD  - King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, Division 
      of Imaging Sciences, St Thomas' Hospital, UK; Department of Internal Medicine, 
      University of Torino, Italy. Electronic address: amedeo.chiribiri@kcl.ac.uk.
FAU - Leuzzi, S
AU  - Leuzzi S
AD  - Division of Cardiology, Cardinal Massaia Hospital, University of Torino, Asti, 
      Italy.
FAU - Conte, M R
AU  - Conte MR
AD  - Division of Cardiology, A.O. Ordine Mauriziano di Torino Presidio Umberto I, 
      Torino, Italy.
FAU - Bongioanni, S
AU  - Bongioanni S
AD  - Division of Cardiology, A.O. Ordine Mauriziano di Torino Presidio Umberto I, 
      Torino, Italy.
FAU - Bratis, K
AU  - Bratis K
AD  - King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, Division 
      of Imaging Sciences, St Thomas' Hospital, UK.
FAU - Olivotti, L
AU  - Olivotti L
AD  - King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, Division 
      of Imaging Sciences, St Thomas' Hospital, UK; Department of Cardiology, Santa 
      Corona Hospital, Pietra Ligure, Italy.
FAU - De Rosa, C
AU  - De Rosa C
AD  - Division of Cardiology, A.O. Ordine Mauriziano di Torino Presidio Umberto I, 
      Torino, Italy.
FAU - Lardone, E
AU  - Lardone E
AD  - Division of Cardiology, A.O. Ordine Mauriziano di Torino Presidio Umberto I, 
      Torino, Italy.
FAU - Di Donna, P
AU  - Di Donna P
AD  - Division of Cardiology, Cardinal Massaia Hospital, University of Torino, Asti, 
      Italy.
FAU - Villa, A D M
AU  - Villa AD
AD  - King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, Division 
      of Imaging Sciences, St Thomas' Hospital, UK.
FAU - Cesarani, F
AU  - Cesarani F
AD  - Department of Radiology, Cardinal Massaia Hospital, Asti, Italy.
FAU - Nagel, E
AU  - Nagel E
AD  - King's College London, Wellcome Trust/EPSRC Medical Engineering Centre, Division 
      of Imaging Sciences, St Thomas' Hospital, UK.
FAU - Gaita, F
AU  - Gaita F
AD  - Department of Internal Medicine, University of Torino, Italy; Division of 
      Cardiology, Cardinal Massaia Hospital, University of Torino, Asti, Italy.
FAU - Bonamini, R
AU  - Bonamini R
AD  - Department of Internal Medicine, University of Torino, Italy.
LA  - eng
GR  - WT 088641/Z/09/Z/Wellcome Trust/United Kingdom
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150207
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Hypertrophic/*physiopathology
MH  - Contrast Media
MH  - *Coronary Circulation
MH  - *Death, Sudden, Cardiac
MH  - Echocardiography
MH  - Female
MH  - Fibrosis
MH  - Hemodynamics
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Italy
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Organometallic Compounds
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Rest
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC4398331
EDAT- 2015/02/11 06:00
MHDA- 2015/06/05 06:00
PMCR- 2015/05/01
CRDT- 2015/02/10 06:00
PHST- 2014/10/07 00:00 [received]
PHST- 2014/12/16 00:00 [revised]
PHST- 2014/12/29 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/06/05 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - S0009-9260(15)00022-7 [pii]
AID - 10.1016/j.crad.2014.12.018 [doi]
PST - ppublish
SO  - Clin Radiol. 2015 May;70(5):495-501. doi: 10.1016/j.crad.2014.12.018. Epub 2015 
      Feb 7.