PMID- 25659938
OWN - NLM
STAT- MEDLINE
DCOM- 20150604
LR  - 20161125
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 70
IP  - 5
DP  - 2015 May
TI  - Pulmonary light-chain deposition disease: CT and pathology findings in nine 
      patients.
PG  - 515-22
LID - S0009-9260(15)00027-6 [pii]
LID - 10.1016/j.crad.2015.01.002 [doi]
AB  - AIM: To review the clinical features of nine patients with pulmonary light-chain 
      deposition disease (LCDD) and record their high-resolution CT (HRCT) and 
      histopathological findings. MATERIALS AND METHODS: Patients with a diagnosis of 
      LCDD on lung biopsy specimen were retrospectively identified. The HRCT 
      characteristics of nodules, cysts, and ancillary findings; change at follow-up; 
      and histopathological findings were documented. RESULTS: Features common to all 
      nine cases were thin-walled cysts. In seven cases, vessels traversing the cysts 
      were identified. The majority of patients (8/9) had at least one pulmonary 
      nodule. There was no zonal predominance of either cysts or nodules. The disease 
      appeared stable in the majority of cases with no serial change in HRCT 
      appearances (5/6 cases with follow-up data, mean duration 29 months). CONCLUSION: 
      To the authors' knowledge, this is the largest series of pulmonary LCDD patients 
      in the literature, and the first systematic assessment of HRCT findings. 
      Pulmonary cysts are a unifying feature, usually with pulmonary nodules, and 
      serial change on HRCT is unusual.
CI  - Copyright (c) 2015 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Sheard, S
AU  - Sheard S
AD  - Department of Radiology, St George's Hospital, Blackshaw Road, London, SW17 0QT, 
      UK.
FAU - Nicholson, A G
AU  - Nicholson AG
AD  - Department of Histopathology, Royal Brompton and Harefield NHS Trust, Sydney 
      Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, 
      London, UK.
FAU - Edmunds, L
AU  - Edmunds L
AD  - Department of Histopathology, Royal Brompton and Harefield NHS Trust, Sydney 
      Street, London, SW3 6NP, UK.
FAU - Wotherspoon, A C
AU  - Wotherspoon AC
AD  - Department of Histopathology, Royal Marsden Hospital, Fulham Road, SW3 6JJ, UK.
FAU - Hansell, D M
AU  - Hansell DM
AD  - Department of Radiology, Royal Brompton and Harefield NHS Trust, Sydney Street, 
      London, SW3 6NP, UK. Electronic address: david.hansell@rbht.nhs.uk.
LA  - eng
PT  - Journal Article
DEP - 20150207
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Female
MH  - Humans
MH  - *Immunoglobulin Light Chains
MH  - Lung Diseases/*diagnostic imaging/pathology
MH  - Male
MH  - Middle Aged
MH  - Paraproteinemias/*diagnostic imaging/pathology
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2015/02/11 06:00
MHDA- 2015/06/05 06:00
CRDT- 2015/02/10 06:00
PHST- 2014/07/12 00:00 [received]
PHST- 2015/01/01 00:00 [revised]
PHST- 2015/01/06 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/06/05 06:00 [medline]
AID - S0009-9260(15)00027-6 [pii]
AID - 10.1016/j.crad.2015.01.002 [doi]
PST - ppublish
SO  - Clin Radiol. 2015 May;70(5):515-22. doi: 10.1016/j.crad.2015.01.002. Epub 2015 
      Feb 7.