PMID- 25661067
OWN - NLM
STAT- MEDLINE
DCOM- 20170413
LR  - 20221207
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 211
IP  - 4
DP  - 2015 Apr
TI  - In situ increased chemokine expression in human cervical intraepithelial 
      neoplasia.
PG  - 281-5
LID - S0344-0338(15)00004-7 [pii]
LID - 10.1016/j.prp.2015.01.002 [doi]
AB  - Chemokines play a role in tumor-inflammation and angiogenesis that could be 
      involved in tumor progression. Monocyte chemoattractant protein-1 (MCP-1), 
      Interleukin-8 (IL-8) and macrophage inflammatory proteins (MIP) have been 
      identified in tumor tissues of patients with different neoplasms. Therefore, the 
      aim of the current study was to investigate the expressions of MCP-1, IL-8 and 
      MIP-1alpha, mononuclear leukocyte infiltration and leukocyte/chemokine expressions in 
      cervical tissues from patients with cervical intraepithelial neoplasia (CIN) and 
      controls. MCP-1, IL-8 and MIP-1alpha expressions and leukocyte infiltration were 
      determined by indirect immunofluorescence in cervix biopsies from CIN patients 
      (n=65) and 7 normal controls. Increased expressions of MCP-1 and IL-8 in CIN were 
      observed. Increment of lymphocyte infiltration and coexpression of CD3/MCP-1 and 
      CD3/IL-8 were found in CIN. CD3/MCP-1 cell percentage was found decreased and 
      CD3/IL-8 percentage increased according to the CIN evolution. MIP-1alpha remained 
      similar to control values. The increased expression of MCP-1 and IL-8 in cervical 
      neoplasia may lead to tumor progression.
CI  - Copyright (c) 2015 Elsevier GmbH. All rights reserved.
FAU - Carrero, Yenddy
AU  - Carrero Y
AD  - Regional Laboratory of Virological Reference, Faculty of Medicine, Zulia 
      University, Maracaibo, Venezuela.
FAU - Mosquera, Jesus
AU  - Mosquera J
AD  - Institute of Clinical Investigation "Dr. Americo Negrette," Faculty of Medicine, 
      Zulia University, Maracaibo, Venezuela. Electronic address: 
      mosquera99ve@yahoo.com.
FAU - Callejas, Diana
AU  - Callejas D
AD  - Regional Laboratory of Virological Reference, Faculty of Medicine, Zulia 
      University, Maracaibo, Venezuela.
FAU - Alvarez-Mon, Melchor
AU  - Alvarez-Mon M
AD  - Department of Immune System Diseases and Oncology, University Hospital "Principe 
      de Asturias", Alcala University, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150120
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL3 protein, human)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokines)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Chemokine CCL2/metabolism
MH  - Chemokine CCL3/metabolism
MH  - Chemokines/*metabolism
MH  - Female
MH  - Humans
MH  - Interleukin-8/metabolism
MH  - Leukocytes/immunology/metabolism
MH  - Uterine Cervical Neoplasms/*immunology/metabolism
MH  - Uterine Cervical Dysplasia/*immunology/metabolism
OTO - NOTNLM
OT  - Cervical intraepithelial neoplasia
OT  - Chemokines
EDAT- 2015/02/11 06:00
MHDA- 2017/04/14 06:00
CRDT- 2015/02/10 06:00
PHST- 2013/12/06 00:00 [received]
PHST- 2014/12/01 00:00 [revised]
PHST- 2015/01/08 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2017/04/14 06:00 [medline]
AID - S0344-0338(15)00004-7 [pii]
AID - 10.1016/j.prp.2015.01.002 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2015 Apr;211(4):281-5. doi: 10.1016/j.prp.2015.01.002. Epub 
      2015 Jan 20.