PMID- 25661477
OWN - NLM
STAT- MEDLINE
DCOM- 20151216
LR  - 20150303
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 89
IP  - 2
DP  - 2015
TI  - Long-term data from the Swiss pulmonary hypertension registry.
PG  - 127-40
LID - 10.1159/000370125 [doi]
AB  - BACKGROUND: Registries are important for real-life epidemiology on different 
      pulmonary hypertension (PH) groups. OBJECTIVE: To provide long-term data of the 
      Swiss PH registry of 1998-2012. METHODS: PH patients have been classified into 5 
      groups and registered upon written informed consent at 5 university and 8 
      associated hospitals since 1998. New York Heart Association (NYHA) class, 6-min 
      walk distance, hemodynamics and therapy were registered at baseline. Patients 
      were regularly followed, and therapy and events (death, transplantation, 
      endarterectomy or loss to follow-up) registered. The data were stratified 
      according to the time of diagnosis into prevalent before 2000 and incident during 
      2000-2004, 2005-2008 and 2009-2012. RESULTS: From 996 (53% female) PH patients, 
      549 had pulmonary arterial hypertension (PAH), 36 PH due to left heart disease, 
      127 due to lung disease, 249 to chronic thromboembolic PH (CTEPH) and 35 to 
      miscellaneous PH. Age and BMI significantly increased over time, whereas 
      hemodynamic severity decreased. Overall, event-free survival was 84, 72, 64 and 
      58% for the years 1-4 and similar for time periods since 2000, but better during 
      the more recent periods for PAH and CTEPH. Of all PAH cases, 89% had target 
      medical therapy and 43% combination therapy. Of CTEPH patients, 14 and 2% 
      underwent pulmonary endarterectomy or transplantation, respectively; 87% were 
      treated with PAH target therapy. CONCLUSION: Since 2000, the incident Swiss PH 
      patients registered were older, hemodynamically better and mostly treated with 
      PAH target therapies. Survival has been better for PAH and CTEPH diagnosed since 
      2008 compared with earlier diagnosis or other classifications.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Mueller-Mottet, Severine
AU  - Mueller-Mottet S
AD  - Pulmonary Clinic, University Hospital Zurich, Zurich, Switzerland.
FAU - Stricker, Hans
AU  - Stricker H
FAU - Domenighetti, Guido
AU  - Domenighetti G
FAU - Azzola, Andrea
AU  - Azzola A
FAU - Geiser, Thomas
AU  - Geiser T
FAU - Schwerzmann, Markus
AU  - Schwerzmann M
FAU - Weilenmann, Daniel
AU  - Weilenmann D
FAU - Schoch, Otto
AU  - Schoch O
FAU - Fellrath, Jean-Marc
AU  - Fellrath JM
FAU - Rochat, Thierry
AU  - Rochat T
FAU - Lador, Frederic
AU  - Lador F
FAU - Beghetti, Maurice
AU  - Beghetti M
FAU - Nicod, Laurent
AU  - Nicod L
FAU - Aubert, John-David
AU  - Aubert JD
FAU - Popov, Vladimir
AU  - Popov V
FAU - Speich, Rudolf
AU  - Speich R
FAU - Keusch, Stephan
AU  - Keusch S
FAU - Hasler, Elisabeth
AU  - Hasler E
FAU - Huber, Lars C
AU  - Huber LC
FAU - Grendelmeier, Peter
AU  - Grendelmeier P
FAU - Tamm, Michael
AU  - Tamm M
FAU - Ulrich, Silvia
AU  - Ulrich S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150131
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
SB  - IM
EIN - Respiration. 2015;89(5)373. Domeninghetti, Guido [corrected to Domenighetti, 
      Guido
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Registries
MH  - Switzerland/epidemiology
MH  - Young Adult
EDAT- 2015/02/11 06:00
MHDA- 2015/12/19 06:00
CRDT- 2015/02/10 06:00
PHST- 2014/10/09 00:00 [received]
PHST- 2014/11/21 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
AID - 000370125 [pii]
AID - 10.1159/000370125 [doi]
PST - ppublish
SO  - Respiration. 2015;89(2):127-40. doi: 10.1159/000370125. Epub 2015 Jan 31.