PMID- 25661794
OWN - NLM
STAT- MEDLINE
DCOM- 20160331
LR  - 20150619
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 104
IP  - 7
DP  - 2015 Jul
TI  - Airway hyper-responsiveness to mannitol provides a good evaluation of atopy in 
      childhood asthma.
PG  - 718-23
LID - 10.1111/apa.12968 [doi]
AB  - AIM: The relationship between airway hyper-responsiveness (AHR) and atopy has 
      been previously investigated, but there are still some issues to be clarified. 
      The aim of this study was to assess the link between AHR and mannitol and atopy 
      in asthmatic children. METHODS: We evaluated 44 children with asthma, aged 6-16 
      years of age, using skin prick tests (SPTs), serum total and specific 
      immunoglobulin E (IgE) levels and the mannitol challenge test (MCT). RESULTS: We 
      found a good correlation between AHR to mannitol and specific IgE against 
      Dermatophagoides pteronissinus (r = -0.66, p < 0.001) and a weak correlation with 
      specific IgE against dog dander (r = -0.33, p = 0.01) and Aspergillus fumigatus 
      (r = -0.23, p = 0.02). Furthermore, we found a weak correlation between AHR to 
      mannitol and serum total IgE (r = -0.30; p = 0.03), the sum of specific IgE to 
      aeroallergens (r = -0.37, p = 0.01) and the number of positive SPTs (r = -0.31, p 
      = 0.02). CONCLUSION: Measuring AHR with MCT might provide an accurate evaluation 
      of the degree of atopy in children. The patients with a higher degree of atopy 
      were significantly more reactive to mannitol. In clinical practice, these results 
      indicate that children with asthma who are more atopic may require more intensive 
      treatment strategies to reduce AHR.
CI  - (c)2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
FAU - Attanasi, M
AU  - Attanasi M
AD  - Allergy and Respiratory Diseases Clinic, Department of Paediatrics, University of 
      Chieti, Chieti, Italy.
FAU - Rapino, D
AU  - Rapino D
AD  - Allergy and Respiratory Diseases Clinic, Department of Paediatrics, University of 
      Chieti, Chieti, Italy.
FAU - Marcovecchio, M L
AU  - Marcovecchio ML
AD  - Department of Paediatrics, University of Chieti, Chieti, Italy.
FAU - Consilvio, N P
AU  - Consilvio NP
AD  - Allergy and Respiratory Diseases Clinic, Department of Paediatrics, University of 
      Chieti, Chieti, Italy.
FAU - Scaparrotta, A
AU  - Scaparrotta A
AD  - Allergy and Respiratory Diseases Clinic, Department of Paediatrics, University of 
      Chieti, Chieti, Italy.
FAU - Cingolani, A
AU  - Cingolani A
AD  - Allergy and Respiratory Diseases Clinic, Department of Paediatrics, University of 
      Chieti, Chieti, Italy.
FAU - Di Pillo, S
AU  - Di Pillo S
AD  - Allergy and Respiratory Diseases Clinic, Department of Paediatrics, University of 
      Chieti, Chieti, Italy.
FAU - Chiarelli, F
AU  - Chiarelli F
AD  - Department of Paediatrics, University of Chieti, Chieti, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150331
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3OWL53L36A (Mannitol)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Asthma/blood/*diagnosis/*physiopathology
MH  - Bronchial Hyperreactivity/blood/*chemically induced
MH  - *Bronchial Provocation Tests
MH  - Child
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - *Mannitol
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Airway hyper-responsiveness
OT  - Asthma
OT  - Atopy
OT  - Children
OT  - Mannitol
EDAT- 2015/02/11 06:00
MHDA- 2016/04/01 06:00
CRDT- 2015/02/10 06:00
PHST- 2014/05/09 00:00 [received]
PHST- 2014/12/11 00:00 [revised]
PHST- 2015/02/02 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2016/04/01 06:00 [medline]
AID - 10.1111/apa.12968 [doi]
PST - ppublish
SO  - Acta Paediatr. 2015 Jul;104(7):718-23. doi: 10.1111/apa.12968. Epub 2015 Mar 31.