PMID- 25662277
OWN - NLM
STAT- MEDLINE
DCOM- 20160909
LR  - 20220311
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 418 Pt 1
DP  - 2015 Dec 15
TI  - Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal 
      mammals.
PG  - 74-88
LID - S0303-7207(15)00035-0 [pii]
LID - 10.1016/j.mce.2015.01.024 [doi]
AB  - Most aspects of energy metabolism display clear variations during day and night. 
      This daily rhythmicity of metabolic functions, including hormone release, is 
      governed by a circadian system that consists of the master clock in the 
      suprachiasmatic nuclei of the hypothalamus (SCN) and many secondary clocks in the 
      brain and peripheral organs. The SCN control peripheral timing via the autonomic 
      and neuroendocrine system, as well as via behavioral outputs. The sleep-wake 
      cycle, the feeding/fasting rhythm and most hormonal rhythms, including that of 
      leptin, ghrelin and glucocorticoids, usually show an opposite phase (relative to 
      the light-dark cycle) in diurnal and nocturnal species. By contrast, the SCN 
      clock is most active at the same astronomical times in these two categories of 
      mammals. Moreover, in both species, pineal melatonin is secreted only at night. 
      In this review we describe the current knowledge on the regulation of glucose and 
      lipid metabolism by central and peripheral clock mechanisms. Most experimental 
      knowledge comes from studies in nocturnal laboratory rodents. Nevertheless, we 
      will also mention some relevant findings in diurnal mammals, including humans. It 
      will become clear that as a consequence of the tight connections between the 
      circadian clock system and energy metabolism, circadian clock impairments (e.g., 
      mutations or knock-out of clock genes) and circadian clock misalignments (such as 
      during shift work and chronic jet-lag) have an adverse effect on energy 
      metabolism, that may trigger or enhancing obese and diabetic symptoms.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Kumar Jha, Pawan
AU  - Kumar Jha P
AD  - Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, 
      Amsterdam, The Netherlands; Regulation of Circadian Clocks Team, Institute of 
      Cellular and Integrative Neurosciences, UPR3212, Centre National de la Recherche 
      Scientifique (CNRS), University of Strasbourg, France; International Associated 
      Laboratory LIA1061 Understanding the Neural Basis of Diurnality, CNRS, France and 
      the Netherlands.
FAU - Challet, Etienne
AU  - Challet E
AD  - Regulation of Circadian Clocks Team, Institute of Cellular and Integrative 
      Neurosciences, UPR3212, Centre National de la Recherche Scientifique (CNRS), 
      University of Strasbourg, France; International Associated Laboratory LIA1061 
      Understanding the Neural Basis of Diurnality, CNRS, France and the Netherlands.
FAU - Kalsbeek, Andries
AU  - Kalsbeek A
AD  - Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, 
      Amsterdam, The Netherlands; International Associated Laboratory LIA1061 
      Understanding the Neural Basis of Diurnality, CNRS, France and the Netherlands; 
      Department of Endocrinology and Metabolism, Academic Medical Center (AMC), 
      University of Amsterdam, The Netherlands. Electronic address: 
      a.kalsbeek@amc.uva.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150207
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Carbohydrate Metabolism/*physiology
MH  - Circadian Clocks/*physiology
MH  - Circadian Rhythm/*physiology
MH  - Glucose/*metabolism
MH  - Humans
MH  - Hypothalamus/metabolism
MH  - Lipid Metabolism/*physiology
MH  - Suprachiasmatic Nucleus/metabolism
OTO - NOTNLM
OT  - Autonomic nervous system
OT  - Circadian rhythm
OT  - Glucose metabolism
OT  - Hypothalamus
OT  - Lipid metabolism
OT  - Suprachiasmatic nucleus
EDAT- 2015/02/11 06:00
MHDA- 2016/09/10 06:00
CRDT- 2015/02/10 06:00
PHST- 2014/11/10 00:00 [received]
PHST- 2015/01/12 00:00 [revised]
PHST- 2015/01/19 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2016/09/10 06:00 [medline]
AID - S0303-7207(15)00035-0 [pii]
AID - 10.1016/j.mce.2015.01.024 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2015 Dec 15;418 Pt 1:74-88. doi: 10.1016/j.mce.2015.01.024. 
      Epub 2015 Feb 7.