PMID- 25663815 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220129 IS - 1380-3743 (Print) IS - 1572-9788 (Electronic) IS - 1380-3743 (Linking) VI - 35 IP - 2 DP - 2015 TI - Using the UK reference population Avalon x Cadenza as a platform to compare breeding strategies in elite Western European bread wheat. PG - 70 LID - 70 AB - Wheat breeders select for qualitative and quantitative traits, the latter often detected as quantitative trait loci (QTL). It is, however, a long procedure from QTL discovery to the successful introduction of favourable alleles into new elite varieties and finally into farmers' crops. As a proof of principle for this process, QTL for grain yield (GY), yield components, plant height (PH), ear emergence (EM), solid stem (SS) and yellow rust resistance (Yr) were identified in segregating UK bread wheat reference population, Avalon x Cadenza. Among the 163 detected QTL were several not reported before: 17 for GY, the major GY QTL on 2D; a major SS QTL on 3B; and Yr6 on 7B. Common QTL were identified on ten chromosomes, most interestingly, grain number (GN) was found to be associated with Rht-D1b; and GY and GN with a potential new allele of Rht8. The interaction of other QTL with GY and yield components was discussed in the context of designing a UK breeding target genotype. Desirable characteristics would be: similar PH and EM to Avalon; Rht-D1b and Vrn-A1b alleles; high TGW and GN; long and wide grains; a large root system, resistance to diseases; and maximum GY. The potential of the identified QTL maximising transgressive segregation to produce a high-yielding and resilient genotype was demonstrated by simulation. Moreover, simulating breeding strategies with F(2) enrichment revealed that the F(2)-DH procedure was superior to the RIL and the modified SSD procedure to achieve that genotype. The proposed strategies of parent selection and breeding methodology can be used as guidance for marker-assisted wheat breeding. FAU - Ma, Juan AU - Ma J AD - Institute of Crop Science, The National Key Facility for Crop Gene Resources and Genetic Improvement, and CIMMYT China, Chinese Academy of Agricultural Sciences, No. 12 Zhongguancun South Street, Beijing, 100081 China ; John Innes Centre, Norwich Research Park, Norwich, NR4 7UH UK. FAU - Wingen, Luzie U AU - Wingen LU AD - John Innes Centre, Norwich Research Park, Norwich, NR4 7UH UK. FAU - Orford, Simon AU - Orford S AD - John Innes Centre, Norwich Research Park, Norwich, NR4 7UH UK. FAU - Fenwick, Paul AU - Fenwick P AD - Limagrain UK Limited, Rothwell, Market Rasen, Lincolnshire, LN7 6DT UK. FAU - Wang, Jiankang AU - Wang J AD - Institute of Crop Science, The National Key Facility for Crop Gene Resources and Genetic Improvement, and CIMMYT China, Chinese Academy of Agricultural Sciences, No. 12 Zhongguancun South Street, Beijing, 100081 China. FAU - Griffiths, Simon AU - Griffiths S AD - John Innes Centre, Norwich Research Park, Norwich, NR4 7UH UK. LA - eng GR - BBS/E/J/000C0617/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - BBS/E/J/000C0635/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - BBS/E/J/000CA358/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom GR - BBS/E/J/000CA393/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom PT - Journal Article DEP - 20150205 PL - Netherlands TA - Mol Breed JT - Molecular breeding : new strategies in plant improvement JID - 9506703 PMC - PMC4317512 OTO - NOTNLM OT - Breeding by design OT - Phenotype prediction OT - Pleiotropy OT - QTL linkage OT - Simulation EDAT- 2015/02/11 06:00 MHDA- 2015/02/11 06:01 PMCR- 2015/02/05 CRDT- 2015/02/10 06:00 PHST- 2014/05/09 00:00 [received] PHST- 2014/09/15 00:00 [accepted] PHST- 2015/02/10 06:00 [entrez] PHST- 2015/02/11 06:00 [pubmed] PHST- 2015/02/11 06:01 [medline] PHST- 2015/02/05 00:00 [pmc-release] AID - 268 [pii] AID - 10.1007/s11032-015-0268-7 [doi] PST - ppublish SO - Mol Breed. 2015;35(2):70. doi: 10.1007/s11032-015-0268-7. Epub 2015 Feb 5.