PMID- 25663875
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210103
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 9
IP  - 3
DP  - 2015 Mar
TI  - CD14(+)HLA-DR(low/-) expression: A novel prognostic factor in chronic lymphocytic 
      leukemia.
PG  - 1167-1172
AB  - Currently, no prognostic factors exist for determining the host immune status of 
      chronic lymphocytic leukemia (CLL) patients. Therefore, the present report 
      analyzed cluster of differentiation 14 (CD14)(+) human leukocyte antigen 
      (HLA)-DR(low/-) myeloid-derived suppressor cells (MDSC) from 49 CLL patients and 
      demonstrated that these cells were significantly expanded in all CLL patients 
      when compared with monoclonal B cell lymphocytosis patients and healthy 
      volunteers. Furthermore, upregulation of CD14(+)HLA-DR(low/-) MDSCs was 
      correlated with CLL tumor progression and a poor prognosis for CLL patients, and 
      CD14(+)HLA-DR(low/-) MDSCs were significantly correlated with the presence of 
      CD4(+) T and CD5(+)CD19(+) cells in CLL patients, which could significantly 
      inhibit the CD4(+) T-cell immune response, contributing to CLL cell progression 
      in CLL patients.
FAU - Liu, Jinlin
AU  - Liu J
AD  - Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, 
      Hangzhou, Zhejiang 310004, P.R. China.
FAU - Zhou, Yonglie
AU  - Zhou Y
AD  - Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, 
      Hangzhou, Zhejiang 310004, P.R. China.
FAU - Huang, Qiang
AU  - Huang Q
AD  - Department of Hematology, Zhejiang Provincial People's Hospital, Hangzhou, 
      Zhejiang 310004, P.R. China.
FAU - Qiu, Liannv
AU  - Qiu L
AD  - Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, 
      Hangzhou, Zhejiang 310004, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20141217
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4314977
OTO - NOTNLM
OT  - CD14+HLA-DRlow/-
OT  - chronic lymphocytic leukemia
OT  - prognostic factor
EDAT- 2015/02/11 06:00
MHDA- 2015/02/11 06:01
PMCR- 2014/12/17
CRDT- 2015/02/10 06:00
PHST- 2014/08/08 00:00 [received]
PHST- 2014/11/06 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/02/11 06:01 [medline]
PHST- 2014/12/17 00:00 [pmc-release]
AID - ol-09-03-1167 [pii]
AID - 10.3892/ol.2014.2808 [doi]
PST - ppublish
SO  - Oncol Lett. 2015 Mar;9(3):1167-1172. doi: 10.3892/ol.2014.2808. Epub 2014 Dec 17.