PMID- 25664048
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150209
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 7
IP  - 12
DP  - 2014
TI  - Association of TBX2 and P21 expression with clinicopathological features and 
      survival of laryngeal squamous cell carcinoma.
PG  - 5394-402
AB  - BACKGROUND: The expression of P21 and TBX2 in laryngeal squamous cell carcinoma 
      (LSCC) and their corresponding adjacent normal laryngeal tissues, as well as 
      their association with clinical pathological features and survival remain 
      unclear. METHOD: we used the RT-PCR and immunohistochemistry to detect their mRNA 
      and protein levels in 75 LSCC patients. We also use log-rank test and Cox models 
      to compare survival among different groups. RESULTS: The mRNA expression level of 
      TBX2 was up-regulated, while P21 was down-regulated in LSCC compared with their 
      matched adjacent laryngeal tissues (All P < 0.001). The expression of P21 was 
      correlated with tumor stage, lymph node metastasis and smoking; and TBX2 
      expression was associated with lymph node metastasis, differentiation degree and 
      smoking (All P < 0.05). Patients with high TBX2 and low P21 expression had 
      significantly worse survival than those with low TBX2 and high P21 expression, 
      respectively (All P < 0.05). A significant correlation between expression of TBX2 
      and P21 (Pearson, P < 0.05) was observed. Furthermore, multivariable analysis 
      showed that patients with low TBX2 and high P21 expression alone had a 
      significantly reduced risk for overall death compared with those with low TBX2 
      and high P21 expression. The risk for overall death was even lower for patients 
      with both low and high expression of both genes than any other co-expression 
      status of both genes (HR, 0.1; 95% CI, 0.0-0.9). CONCLUSION: These results 
      suggest that abnormal expression of P21 and TBX2 in tumors may jointly, or 
      individually, predict poor prognosis of LSCC.
FAU - Huang, Yongjiu
AU  - Huang Y
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, 
      Capital Medical University, Key Laboratory of Otolaryngology Head and Neck 
      Surgery (Capital Medical University), Ministry of Education Beijing 100730, China 
      ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of 
      Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and 
      Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
FAU - Li, Zufei
AU  - Li Z
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, 
      Capital Medical University, Key Laboratory of Otolaryngology Head and Neck 
      Surgery (Capital Medical University), Ministry of Education Beijing 100730, China 
      ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of 
      Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and 
      Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
FAU - Zhong, Qi
AU  - Zhong Q
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, 
      Capital Medical University, Key Laboratory of Otolaryngology Head and Neck 
      Surgery (Capital Medical University), Ministry of Education Beijing 100730, China 
      ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of 
      Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and 
      Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
FAU - Li, Guojun
AU  - Li G
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, 
      Capital Medical University, Key Laboratory of Otolaryngology Head and Neck 
      Surgery (Capital Medical University), Ministry of Education Beijing 100730, China 
      ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of 
      Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and 
      Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, 
      Capital Medical University, Key Laboratory of Otolaryngology Head and Neck 
      Surgery (Capital Medical University), Ministry of Education Beijing 100730, China 
      ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of 
      Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and 
      Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
FAU - Huang, Zhigang
AU  - Huang Z
AD  - Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, 
      Capital Medical University, Key Laboratory of Otolaryngology Head and Neck 
      Surgery (Capital Medical University), Ministry of Education Beijing 100730, China 
      ; Department of Otolaryngology Head and Neck Surgery, People's Hospital of 
      Taizhou Taizhou 225300, Jiangsu, China ; Department of Head and Neck Surgery and 
      Epidemiology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
LA  - eng
PT  - Journal Article
DEP - 20141215
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4307495
OTO - NOTNLM
OT  - LSCC
OT  - P21
OT  - TBX2
OT  - survival
EDAT- 2015/02/11 06:00
MHDA- 2015/02/11 06:01
PMCR- 2014/12/15
CRDT- 2015/02/10 06:00
PHST- 2014/10/06 00:00 [received]
PHST- 2014/12/08 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/02/11 06:01 [medline]
PHST- 2014/12/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2014 Dec 15;7(12):5394-402. eCollection 2014.