PMID- 25664065
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150209
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 7
IP  - 12
DP  - 2014
TI  - MicroRNA-9 as a novel prognostic biomarker in human laryngeal squamous cell 
      carcinoma.
PG  - 5523-8
AB  - In the present study, we aimed to detect microRNA-9 (miR-9) expression level and 
      its clinical significance in laryngeal squamous cell carcinomas (LSCC). 103 
      patients who were diagnosed with LSCC and treated between March 2010 and June 
      2013 were enrolled in this study. Expression levels of miR-9 were detected by 
      real-time quantitative RT-PCR assay. Survival curves were estimated using the 
      Kaplan-Meier method, and differences between them were evaluated by the log-rank 
      test. Cox proportional hazard regression test was used to estimate univariate and 
      multivariate hazard ratios for prognosis. We found that miR-9 levels were 
      significantly higher in LSCC tissues compared with matched non-cancerous tissues 
      [4.55 (164-6.75) vs. 2.07 (0.89-2.65), P < 0.05]. The level of miR-9 in LSCC was 
      strongly correlated with tumor differentiation (P = 0.031), thyroid cartilage 
      invasion (P = 0.024), lymph node metastasis (P = 0.009) and clinical TNM stage (P 
      = 0.011). The log-rank test showed that the survival time was significantly 
      different between groups with high and low expression of miR-9 (Log Rank test, P 
      = 0.014). Furthermore, Cox regression multivariate analysis demonstrated that 
      miR-9 expression was an independent prognostic factor of outcomes in patients 
      with LSCC after tumour resection (HR = 3.18, 95% CI = 2.19-11.91, P = 0.012). In 
      conclusion, miR-9 expression was up-regulated in LSCC and was significantly 
      associated with the progression and poorer prognosis of LSCC. Therefore, it might 
      be utilized as a useful prognostic biomarker for LSCC.
FAU - Wu, Shuo
AU  - Wu S
AD  - Department of E.N.T., The 4th Affiliated Hospital of Harbin Medical University 
      Harbin 150010, China ; Department of Neck Surgical, The 3rd Affiliated Hospital 
      of Harbin Medical University Harbin 150081, China.
FAU - Jia, Shenshan
AU  - Jia S
AD  - Department of Neck Surgical, The 3rd Affiliated Hospital of Harbin Medical 
      University Harbin 150081, China.
FAU - Xu, Ping
AU  - Xu P
AD  - Department of E.N.T., The 4th Affiliated Hospital of Harbin Medical University 
      Harbin 150010, China.
LA  - eng
PT  - Journal Article
DEP - 20141215
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4307512
OTO - NOTNLM
OT  - MicroRNA
OT  - laryngeal squamous cell carcinoma
OT  - miR-9
OT  - prognostic biomarker
EDAT- 2015/02/11 06:00
MHDA- 2015/02/11 06:01
PMCR- 2014/12/15
CRDT- 2015/02/10 06:00
PHST- 2014/09/24 00:00 [received]
PHST- 2014/11/25 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/02/11 06:01 [medline]
PHST- 2014/12/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2014 Dec 15;7(12):5523-8. eCollection 2014.