PMID- 25664168
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150209
LR  - 20200930
IS  - 2045-7022 (Print)
IS  - 2045-7022 (Electronic)
IS  - 2045-7022 (Linking)
VI  - 5
IP  - 1
DP  - 2015
TI  - Clinical similarities among bradykinin-mediated and mast cell-mediated subtypes 
      of non-hereditary angioedema: a retrospective study.
PG  - 5
LID - 10.1186/s13601-015-0049-8 [doi]
LID - 5
AB  - BACKGROUND: Non-hereditary angioedema (non-HAE) is characterized by local 
      swelling due to self-limiting, subcutaneous or submucosal extravasation of fluid, 
      and can be divided into three subtypes. These subtypes are believed to have 
      different pathophysiological backgrounds and are referred to in recent guidelines 
      as bradykinin-mediated (e.g. caused by angiotensin-converting-enzyme-inhibitors), 
      mast cell-mediated (e.g. angioedema with wheals) or idiopathic (cause unknown). 
      Bradykinin-mediated subtypes are more closely related to hereditary angioedema 
      than the other forms. Because clinical features of these non-HAE subtypes have 
      not been studied in detail, we have looked at the clinical characteristics of 
      symptoms and potential differences in clinical presentation of 
      bradykinin-mediated and mast cell-mediated angioedema (AE) subtypes. METHODS: A 
      questionnaire was sent to patients presenting with AE at our tertiary outpatient 
      clinic to document clinical characteristics, potential triggers and location of 
      AE. The severity of AE attacks was analysed using visual analogue scales (VAS). 
      RESULTS: The questionnaire was returned by 106 patients, of which 104 were 
      included in the analysis. AE with wheals, idiopathic AE, and drug-associated AE 
      occurred in 64 (62%), 25 (24%) and 15 patients (14%) respectively. Most patients 
      (62%) reported prodromal symptoms while 63% reported multiple locations for an 
      attack. Face and oropharynx were the main locations of AE attacks of any subtype 
      while swelling was the symptom most frequently reported as severe. Overall 
      severity of the last attack was indicated as severe by 68% of the patients. There 
      were no differences between the subgroups. CONCLUSION: This similarity in 
      clinical presentation raises the possibility that ACEi-induced, mast 
      cell-mediated and idiopathic AE share common pathways.
FAU - Schulkes, Karlijn J G
AU  - Schulkes KJG
AD  - Department of Dermatology and Allergology, University Medical Center Utrecht 
      (G02.124), PO Box 85.500, Utrecht, 3508 GA The Netherlands.
FAU - Van den Elzen, Mignon T
AU  - Van den Elzen MT
AD  - Department of Dermatology and Allergology, University Medical Center Utrecht 
      (G02.124), PO Box 85.500, Utrecht, 3508 GA The Netherlands.
FAU - Hack, Erik C
AU  - Hack EC
AD  - Department of Dermatology and Allergology, University Medical Center Utrecht 
      (G02.124), PO Box 85.500, Utrecht, 3508 GA The Netherlands.
AD  - Laboratory of Translational Immunology, University Medical Center Utrecht, 
      Utrecht, the Netherlands.
FAU - Otten, Henderikus G
AU  - Otten HG
AD  - Laboratory of Translational Immunology, University Medical Center Utrecht, 
      Utrecht, the Netherlands.
FAU - Bruijnzeel-Koomen, Carla A F M
AU  - Bruijnzeel-Koomen CAFM
AD  - Department of Dermatology and Allergology, University Medical Center Utrecht 
      (G02.124), PO Box 85.500, Utrecht, 3508 GA The Netherlands.
FAU - Knulst, Andre C
AU  - Knulst AC
AD  - Department of Dermatology and Allergology, University Medical Center Utrecht 
      (G02.124), PO Box 85.500, Utrecht, 3508 GA The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20150204
PL  - England
TA  - Clin Transl Allergy
JT  - Clinical and translational allergy
JID - 101576043
PMC - PMC4320604
OTO - NOTNLM
OT  - Angioedema
OT  - Drug-associated
OT  - Idiopathic
OT  - Wheals
EDAT- 2015/02/11 06:00
MHDA- 2015/02/11 06:01
PMCR- 2015/02/04
CRDT- 2015/02/10 06:00
PHST- 2014/08/05 00:00 [received]
PHST- 2015/01/19 00:00 [accepted]
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/02/11 06:01 [medline]
PHST- 2015/02/04 00:00 [pmc-release]
AID - 49 [pii]
AID - 10.1186/s13601-015-0049-8 [doi]
PST - epublish
SO  - Clin Transl Allergy. 2015 Feb 4;5(1):5. doi: 10.1186/s13601-015-0049-8. 
      eCollection 2015.