PMID- 25664836
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20150321
IS  - 1744-8352 (Electronic)
IS  - 1473-7159 (Linking)
VI  - 15
IP  - 4
DP  - 2015 Apr
TI  - The current state of molecular cytogenetics in cancer diagnosis.
PG  - 517-26
LID - 10.1586/14737159.2015.1013032 [doi]
AB  - Cytogenetics and molecular cytogenetics are and will continue to be indispensable 
      tools in cancer diagnostics. Leukemia and lymphoma diagnostics are still emphases 
      of routine (molecular) cytogenetics and corresponding studies of solid tumors 
      gain more and more prominence. Here, first a historical perspective of molecular 
      tumor cytogenetics is provided, which is followed by the basic principles of the 
      fluorescence in situ hybridization (FISH) approach. Finally the current state of 
      molecular cytogenetics in cancer diagnostics is discussed. Nowadays routine 
      diagnostics includes basic FISH approaches rather than multicolor-FISH. The 
      latter together with modern high-throughput methods have their impact on research 
      to identify new tumor-associated genomic regions.
FAU - Liehr, Thomas
AU  - Liehr T
AD  - Jena University Hospital, Friedrich Schiller University, Institute of Human 
      Genetics, Kollegiengasse 10, Postfach, D-07743 Jena, Germany.
FAU - Othman, Moneeb A K
AU  - Othman MA
FAU - Rittscher, Katharina
AU  - Rittscher K
FAU - Alhourani, Eyad
AU  - Alhourani E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150209
PL  - England
TA  - Expert Rev Mol Diagn
JT  - Expert review of molecular diagnostics
JID - 101120777
RN  - 0 (Nucleic Acid Probes)
SB  - IM
MH  - Cytogenetics/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - *Molecular Diagnostic Techniques
MH  - Neoplasms/*diagnosis/*genetics
MH  - Nucleic Acid Probes
OTO - NOTNLM
OT  - copy number variation
OT  - counseling
OT  - cytogenetics
OT  - fluorescence in situ hybridization
OT  - leukemia
OT  - lymphoma
OT  - molecular cytogenetics
OT  - oncogene
OT  - solid tumors
OT  - tumor suppressor gene
EDAT- 2015/02/11 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/10 06:00
PHST- 2015/02/10 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1586/14737159.2015.1013032 [doi]
PST - ppublish
SO  - Expert Rev Mol Diagn. 2015 Apr;15(4):517-26. doi: 10.1586/14737159.2015.1013032. 
      Epub 2015 Feb 9.