PMID- 25665281
OWN - NLM
STAT- MEDLINE
DCOM- 20150310
LR  - 20201209
IS  - 1122-6714 (Print)
IS  - 1122-6714 (Linking)
VI  - 119
IP  - 2
DP  - 2014
TI  - Expression of brain derivated neurotrophic factor and of its receptors: TrKB and 
      p75NT in normal and bile duct ligated rat liver.
PG  - 111-29
AB  - Cholangiocytes are the cells lining the biliary tree from canals of Hering to 
      larger bile ducts. By morphology, they are divided in small and large 
      cholangiocytes, which result heterogeneous at functional and proliferative 
      levels. Proliferating cholangiocytes acquire a neuroendocrine phe- notype, 
      modulated by several factors including neurotrophins. Brain Derivated 
      Neurotrophic Factor (BDNF) is a neurotrophin expressed in the nervous system and 
      also in different types of epithelial and progenitor cells. The aim of the 
      present study is to detect the expression of BDNF and of its two receptors (TrKB 
      and p75NT, or p75NTR) in normal and bile duct ligated (BDL) rat livers. In normal 
      and BDL livers, BDNF and its receptors are expressed by small and large cholan- 
      giocytes and by hepatic progenitors cells. In cholangiocytes, the expression of 
      BDNF and of its receptors changes after different BDL timing. After one or two 
      weeks of BDL, both BDNF and TrKB and p75NT receptors are highly expressed, while 
      after BDL for three weeks BDNF expression is drastically reduced and p75NT 
      receptor prevails on TrKB. The expression of BDNF and of its receptors correlates 
      with the proliferation rate of biliary tree during BDL. Indeed, after one or two 
      weeks of BDL, proliferation prevails on apoptosis, whereas after BDL for three 
      weeks, apoptosis prevails on proliferation. Our morphological results strongly 
      suggest that BDNF plays a role in the remodeling of biliary tree during 
      cholestasis and that it may be involved in the pathophysiology of cholestasic 
      liver diseases.
FAU - Vivacqua, Giorgio
AU  - Vivacqua G
FAU - Renzi, Anastasia
AU  - Renzi A
FAU - Carpino, Guido
AU  - Carpino G
FAU - Franchitto, Antonio
AU  - Franchitto A
FAU - Gaudio, Eugenio
AU  - Gaudio E
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Ital J Anat Embryol
JT  - Italian journal of anatomy and embryology = Archivio italiano di anatomia ed 
      embriologia
JID - 9612303
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 136958-07-1 (Ngfr protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Bile Ducts/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cholestasis/*metabolism/pathology
MH  - Male
MH  - Nerve Tissue Proteins
MH  - Neuroendocrine Cells/*metabolism/pathology
MH  - Rats, Wistar
MH  - Receptor, trkB/*metabolism
MH  - Receptors, Growth Factor
MH  - Receptors, Nerve Growth Factor/*metabolism
EDAT- 2015/02/11 06:00
MHDA- 2015/03/11 06:00
CRDT- 2015/02/11 06:00
PHST- 2015/02/11 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/03/11 06:00 [medline]
PST - ppublish
SO  - Ital J Anat Embryol. 2014;119(2):111-29.