PMID- 25666189
OWN - NLM
STAT- MEDLINE
DCOM- 20160205
LR  - 20181202
IS  - 1349-9157 (Electronic)
IS  - 0449-3060 (Print)
IS  - 0449-3060 (Linking)
VI  - 56
IP  - 3
DP  - 2015 May
TI  - A dosimetric comparison of two-phase adaptive intensity-modulated radiotherapy 
      for locally advanced nasopharyngeal cancer.
PG  - 529-38
LID - 10.1093/jrr/rru119 [doi]
AB  - The purpose of this investigation was to evaluate the potential dosimetric 
      benefits of a two-phase adaptive intensity-modulated radiotherapy (IMRT) protocol 
      for patients with locally advanced nasopharyngeal cancer (NPC). A total of 17 
      patients with locally advanced NPC treated with IMRT had a second computed 
      tomography (CT) scan after 17 fractions in order to apply and continue the 
      treatment with an adapted plan after 20 fractions. To simulate the situation 
      without adaptation, a hybrid plan was generated by applying the optimization 
      parameters of the original treatment plan to the anatomy of the second CT scan. 
      The dose-volume histograms (DVHs) and dose statistics of the hybrid plan and the 
      adapted plan were compared. The mean volume of the ipsilateral and contralateral 
      parotid gland decreased by 6.1 cm(3) (30.5%) and 5.4 cm(3) (24.3%), respectively. 
      Compared with the hybrid plan, the adapted plan provided a higher dose to the 
      target volumes with better homogeneity, and a lower dose to the organs at risk 
      (OARs). The Dmin of all planning target volumes (PTVs) increased. The Dmax of the 
      spinal cord and brainstem were lower in 94% of the patients (1.6-5.9 Gy, P < 
      0.001 and 2.1-9.9 Gy, P < 0.001, respectively). The Dmean of the contralateral 
      parotid decreased in 70% of the patients (range, 0.2-4.4 Gy). We could not find a 
      relationship between dose variability and weight loss. Our two-phase adaptive 
      IMRT protocol improves dosimetric results in terms of target volumes and OARs in 
      patients with locally advanced NPC.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of The Japan 
      Radiation Research Society and Japanese Society for Radiation Oncology.
FAU - Chitapanarux, Imjai
AU  - Chitapanarux I
AD  - Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai 
      University, 110 Intawarorose Road, Chiang Mai, 50200, Thailand imjai@hotmail.com 
      imjai.chitapanarux@cmu.ac.th.
FAU - Chomprasert, Kittisak
AU  - Chomprasert K
AD  - Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai 
      University, 110 Intawarorose Road, Chiang Mai, 50200, Thailand.
FAU - Nobnaop, Wannapa
AU  - Nobnaop W
AD  - Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai 
      University, 110 Intawarorose Road, Chiang Mai, 50200, Thailand.
FAU - Wanwilairat, Somsak
AU  - Wanwilairat S
AD  - Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai 
      University, 110 Intawarorose Road, Chiang Mai, 50200, Thailand.
FAU - Tharavichitkul, Ekasit
AU  - Tharavichitkul E
AD  - Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai 
      University, 110 Intawarorose Road, Chiang Mai, 50200, Thailand.
FAU - Jakrabhandu, Somvilai
AU  - Jakrabhandu S
AD  - Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai 
      University, 110 Intawarorose Road, Chiang Mai, 50200, Thailand.
FAU - Onchan, Wimrak
AU  - Onchan W
AD  - Division of Therapeutic Radiology and Oncology, Faculty of Medicine, Chiang Mai 
      University, 110 Intawarorose Road, Chiang Mai, 50200, Thailand.
FAU - Traisathit, Patrinee
AU  - Traisathit P
AD  - Department of Statistics, Faculty of Science, Chiang Mai University, Chiang Mai, 
      Thailand.
FAU - Van Gestel, Dirk
AU  - Van Gestel D
AD  - Department of Radiotherapy, University Radiotherapy Antwerp, UZA/ZNA, Antwerp, 
      Belgium.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150208
PL  - England
TA  - J Radiat Res
JT  - Journal of radiation research
JID - 0376611
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/*diagnostic imaging/*radiotherapy
MH  - *Radiation Dose Hypofractionation
MH  - Radiography
MH  - Radiometry
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC4426913
OTO - NOTNLM
OT  - adaptive radiotherapy
OT  - intensity-modulated radiation therapy
OT  - nasopharyngeal cancer
OT  - two-phase
EDAT- 2015/02/11 06:00
MHDA- 2016/02/06 06:00
PMCR- 2015/02/08
CRDT- 2015/02/11 06:00
PHST- 2014/06/24 00:00 [received]
PHST- 2014/11/21 00:00 [accepted]
PHST- 2015/02/11 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2016/02/06 06:00 [medline]
PHST- 2015/02/08 00:00 [pmc-release]
AID - rru119 [pii]
AID - 10.1093/jrr/rru119 [doi]
PST - ppublish
SO  - J Radiat Res. 2015 May;56(3):529-38. doi: 10.1093/jrr/rru119. Epub 2015 Feb 8.