PMID- 25668026
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20181113
IS  - 1545-1585 (Electronic)
IS  - 0066-4278 (Print)
IS  - 0066-4278 (Linking)
VI  - 77
DP  - 2015
TI  - Sodium channel beta subunits: emerging targets in channelopathies.
PG  - 481-504
LID - 10.1146/annurev-physiol-021014-071846 [doi]
AB  - Voltage-gated sodium channels (VGSCs) are responsible for the initiation and 
      propagation of action potentials in excitable cells. VGSCs in mammalian brain are 
      heterotrimeric complexes of alpha and beta subunits. Although beta subunits were originally 
      termed auxiliary, we now know that they are multifunctional signaling molecules 
      that play roles in both excitable and nonexcitable cell types and with or without 
      the pore-forming alpha subunit present. beta subunits function in VGSC and potassium 
      channel modulation, cell adhesion, and gene regulation, with particularly 
      important roles in brain development. Mutations in the genes encoding beta subunits 
      are linked to a number of diseases, including epilepsy, sudden death syndromes 
      like SUDEP and SIDS, and cardiac arrhythmia. Although VGSC beta subunit-specific 
      drugs have not yet been developed, this protein family is an emerging therapeutic 
      target.
FAU - O'Malley, Heather A
AU  - O'Malley HA
AD  - Department of Pharmacology, University of Michigan Medical School, Ann Arbor, 
      Michigan 48109; email: lisom@umich.edu.
FAU - Isom, Lori L
AU  - Isom LL
LA  - eng
GR  - R01 NS064245/NS/NINDS NIH HHS/United States
GR  - R01 NS076752/NS/NINDS NIH HHS/United States
GR  - T32 HD007505/HD/NICHD NIH HHS/United States
GR  - U01 NS090364/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Physiol
JT  - Annual review of physiology
JID - 0370600
RN  - 0 (Voltage-Gated Sodium Channel beta Subunits)
SB  - IM
MH  - Arrhythmias, Cardiac/genetics/physiopathology
MH  - Autistic Disorder/genetics/physiopathology
MH  - Cell Adhesion/genetics/physiology
MH  - Channelopathies/*genetics/*physiopathology
MH  - Epilepsy/genetics/physiopathology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Mutation/*genetics
MH  - Neurodegenerative Diseases/genetics/physiopathology
MH  - Protein Processing, Post-Translational/genetics/physiology
MH  - Voltage-Gated Sodium Channel beta Subunits/*genetics/*physiology
PMC - PMC4817109
MID - NIHMS765704
OTO - NOTNLM
OT  - arrhythmia
OT  - cell adhesion
OT  - development
OT  - epilepsy
OT  - neurodegenerative disease
OT  - pain
EDAT- 2015/02/11 06:00
MHDA- 2015/11/18 06:00
PMCR- 2016/04/01
CRDT- 2015/02/11 06:00
PHST- 2015/02/11 06:00 [entrez]
PHST- 2015/02/11 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.1146/annurev-physiol-021014-071846 [doi]
PST - ppublish
SO  - Annu Rev Physiol. 2015;77:481-504. doi: 10.1146/annurev-physiol-021014-071846.