PMID- 25669314
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20150312
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 37
IP  - 2
DP  - 2015 Apr
TI  - Shark cartilage 14 kDa protein as a dendritic cells activator.
PG  - 165-70
LID - 10.3109/08923973.2015.1006370 [doi]
AB  - Low molecular weight components of shark cartilage are reported to have 
      anti-tumor as well as immuno-stimulating effects. Dendritic cells (DCs) are 
      potent antigen-presenting cells (APCs) that have a key role in establishment of 
      anti-cancer immune response. In this study, the effect of 14 kDa protein from 
      shark cartilage was investigated on stimulation and maturation of dendritic 
      cells. The isolated 14 kDa protein from shark cartilage extract was added to DCs 
      medium during overnight culture and their maturation and T cells stimulation 
      potential was investigated. The majority of shark-cartilage-treated DCs expressed 
      higher levels of maturation markers and were more effective in stimulation of 
      allogenic T cells compared with non-treated DCs (p < 0.05). Our results showed 
      that shark cartilage 14 kDa protein can potentially be used in DC-mediated 
      T-cells stimulation and induction of desirable immune responses in clinical 
      trials such as cancer immunotherapy. However, further studies are required to 
      examine this proposal.
FAU - Safari, Elahe
AU  - Safari E
AD  - Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University 
      , Tehran , Iran.
FAU - Hassan, Zuhair M
AU  - Hassan ZM
FAU - Moazzeni, Seyed Mohammad
AU  - Moazzeni SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150211
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Matrilin Proteins)
SB  - IM
MH  - Animals
MH  - *Cartilage
MH  - Dendritic Cells/*drug effects/immunology/*metabolism
MH  - Dogfish
MH  - Matrilin Proteins/isolation & purification/*pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
OTO - NOTNLM
OT  - Allogenic MLR
OT  - T cell stimulation
OT  - dendritic cell
OT  - shark cartilage
OT  - tumor
EDAT- 2015/02/12 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/12 06:00
PHST- 2015/02/12 06:00 [entrez]
PHST- 2015/02/12 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.3109/08923973.2015.1006370 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2015 Apr;37(2):165-70. doi: 
      10.3109/08923973.2015.1006370. Epub 2015 Feb 11.