PMID- 25669655
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20150317
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 97
IP  - 4
DP  - 2015 Apr
TI  - The concept of fraction of drug transported (ft ) with special emphasis on BBB 
      efflux of CNS and antiretroviral drugs.
PG  - 320-3
LID - 10.1002/cpt.72 [doi]
AB  - The fraction of drug transported (ft) into or out of a tissue is a concept useful 
      to understand the impact of transporters on absorption, distribution, metabolism, 
      and excretion (ADME) and tissue distribution of a drug. Here, ft is utilized to 
      explain the impact of transporters on central nervous system (CNS) distribution 
      of drugs, drug interactions (DDI), and to predict the unbound brain concentration 
      (Cu,b) of the drug. The latter is important to ascertain if Cu,b is sufficient 
      for efficacy.
CI  - (c) 2015 American Society for Clinical Pharmacology and Therapeutics.
FAU - Prasad, B
AU  - Prasad B
AD  - Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
FAU - Unadkat, J D
AU  - Unadkat JD
LA  - eng
PT  - Journal Article
DEP - 20150213
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Antiviral Agents)
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - *Antiretroviral Therapy, Highly Active
MH  - Antiviral Agents/*pharmacokinetics
MH  - Biological Transport
MH  - Blood-Brain Barrier/*metabolism
MH  - Carrier Proteins/metabolism
MH  - Central Nervous System/*metabolism
MH  - Drug Interactions
MH  - Humans
MH  - Membrane Transport Proteins/metabolism
MH  - Pharmaceutical Preparations/*metabolism
EDAT- 2015/02/12 06:00
MHDA- 2015/05/13 06:00
CRDT- 2015/02/12 06:00
PHST- 2014/11/24 00:00 [received]
PHST- 2015/01/05 00:00 [revised]
PHST- 2015/01/06 00:00 [accepted]
PHST- 2015/02/12 06:00 [entrez]
PHST- 2015/02/12 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - 10.1002/cpt.72 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2015 Apr;97(4):320-3. doi: 10.1002/cpt.72. Epub 2015 Feb 13.