PMID- 25670619
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20150608
IS  - 2090-2387 (Electronic)
IS  - 1687-1979 (Linking)
VI  - 16
IP  - 1
DP  - 2015 Mar
TI  - Effects of fenugreek, Nigella, and termis seeds in nonalcoholic fatty liver in 
      obese diabetic albino rats.
PG  - 1-9
LID - S1687-1979(14)00096-3 [pii]
LID - 10.1016/j.ajg.2014.12.003 [doi]
AB  - BACKGROUND AND STUDY AIM: Nonalcoholic fatty liver disease (NAFLD) occurs in 
      approximately 80% of cases of type 2 diabetes mellitus (T2DM). This study 
      investigated the effects of some plants used in Saudi Arabia as antidiabetic 
      agents on T2DM and associated fatty liver. MATERIALS AND METHODS: A total of 150 
      adult male albino rats were divided into six experimental groups, each consisting 
      of 25 rats. Twenty-five rats were considered as the control group. Experimental 
      diabetes was induced in the remaining rats by administering a subcutaneous 
      injection of 120 mg/kg of freshly prepared alloxan solution; these rats were 
      classified into five groups: one group did not receive any treatment; the second 
      group was treated with an aqueous extract of a mixture containing fenugreek, 
      Nigella, and termis seeds; the third group was treated with an aqueous extract of 
      Nigella sativa seeds; the fourth group was treated with an aqueous extract of 
      fenugreek seeds; and finally the fifth group was treated with an aqueous extract 
      of termis seeds at a dose of 100 mg/kg body weight. After 4 weeks of treatment, 
      biochemical parameters were calculated, including blood sugar and serum insulin 
      levels. Pancreatic and liver samples were obtained and processed for microscopic 
      evaluation. RESULTS: The usage of each plant alone or a mixture of the plants 
      corrected the glucose and insulin levels. Microscopically, a definite improvement 
      in the number and diameter of beta-cells in the diabetic group was observed. 
      Furthermore, considerable improvement in fatty changes occurring in the liver of 
      experimental animals was observed. The activity of the mixture was the most 
      effective. CONCLUSIONS: The aqueous extract of the seed mixture of the used 
      plants appeared to be a useful agent in improving fatty changes in the liver 
      texture associated with T2DM by reducing hyperglycaemia through an increase in 
      insulin levels, regeneration of beta-cells of the pancreas, and an amelioration of 
      associated dyslipidemia.
CI  - Copyright (c) 2014 Arab Journal of Gastroenterology. Published by Elsevier B.V. All 
      rights reserved.
FAU - Mohamed, Waleed S
AU  - Mohamed WS
AD  - Internal Medicine Department, College of Medicine, Taif University, Saudi Arabia; 
      Tanta University, Tanta, Egypt. Electronic address: wsmohamed1@yahoo.com.
FAU - Mostafa, Ashraf M
AU  - Mostafa AM
AD  - Anatomy and Histology Department, College of Medicine, Taif University, Taif, 
      Saudi Arabia.
FAU - Mohamed, Khaled M
AU  - Mohamed KM
AD  - Pharmacognosy Department, College of Pharmacy, Taif University, Taif, Saudi 
      Arabia.
FAU - Serwah, Abdel Hamid
AU  - Serwah AH
AD  - Internal Medicine Department, College of Medicine, Taif University, Taif, Saudi 
      Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150207
PL  - Egypt
TA  - Arab J Gastroenterol
JT  - Arab journal of gastroenterology : the official publication of the Pan-Arab 
      Association of Gastroenterology
JID - 101298363
RN  - 0 (Plant Extracts)
RN  - 68990-15-8 (fenugreek seed meal)
RN  - 6SW5YHA5NG (Alloxan)
SB  - IM
MH  - Adipose Tissue/*drug effects/metabolism
MH  - *Alloxan
MH  - Analysis of Variance
MH  - Animals
MH  - Diabetes Mellitus, Experimental
MH  - Disease Models, Animal
MH  - Humans
MH  - Male
MH  - *Nigella
MH  - Non-alcoholic Fatty Liver Disease/*drug therapy/pathology
MH  - Obesity
MH  - Phytotherapy/methods
MH  - Plant Extracts/*pharmacology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Saudi Arabia
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
MH  - *Trigonella
OTO - NOTNLM
OT  - Alloxan
OT  - Antidiabetic plants
OT  - Diabetes
OT  - Nonalcoholic fatty liver diseases
OT  - Pancreas
EDAT- 2015/02/12 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/02/12 06:00
PHST- 2014/03/19 00:00 [received]
PHST- 2014/08/30 00:00 [revised]
PHST- 2014/12/21 00:00 [accepted]
PHST- 2015/02/12 06:00 [entrez]
PHST- 2015/02/12 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - S1687-1979(14)00096-3 [pii]
AID - 10.1016/j.ajg.2014.12.003 [doi]
PST - ppublish
SO  - Arab J Gastroenterol. 2015 Mar;16(1):1-9. doi: 10.1016/j.ajg.2014.12.003. Epub 
      2015 Feb 7.