PMID- 2567175
OWN - NLM
STAT- MEDLINE
DCOM- 19890714
LR  - 20220318
IS  - 0252-1172 (Print)
IS  - 0252-1172 (Linking)
VI  - 7
IP  - 2
DP  - 1989
TI  - Antigenic targets in epimembranous glomerulonephritis. Experimental data and 
      potential application in human pathology.
PG  - 85-98
AB  - Although membranous glomerulonephritis (MGN) has been long considered as a 
      prototype of glomerulonephritis (GN) due to the deposition of circulating immune 
      complexes (CIC), a growing body of evidence indicates that immune deposits can 
      also be formed in situ and implicate antigens expressed by glomerular epithelial 
      cells (GEC). Some of these antigens have recently been identified. The first one, 
      gp330 - a 330-kd glycoprotein restricted to the coated pits of GEC and renal 
      brush border (BB) - is responsible for Heymann nephritis, a rat model of MGN. 
      However, it is absent in the human glomerulus and is therefore probably not 
      involved in human cases of MGN, at least in those due to in situ formation of 
      CIC. In addition, by raising monoclonal antibodies against rat and rabbit BB, we 
      have isolated two other BB proteins also expressed on GEC. The latter, 
      respectively identified as dipeptidyl peptidase IV (90 kd) and enkephalinase (85 
      kd), can serve as targets for the formation of short-lived immune deposits. Since 
      they are also detected on human GEC, they might play a role in the pathogenesis 
      of MGN in man.
FAU - Ronco, P
AU  - Ronco P
AD  - INSERM U.64, Hopital Tenon, Paris, France.
FAU - Allegri, L
AU  - Allegri L
FAU - Brianti, E
AU  - Brianti E
FAU - Chatelet, F
AU  - Chatelet F
FAU - Van Leer, E H
AU  - Van Leer EH
FAU - Verroust, P
AU  - Verroust P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Appl Pathol
JT  - Applied pathology
JID - 8308921
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Surface)
RN  - EC 3.4.14.- (Dipeptidyl-Peptidases and Tripeptidyl-Peptidases)
RN  - EC 3.4.14.5 (Dipeptidyl Peptidase 4)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Antigen-Antibody Complex/*immunology
MH  - Antigens, Differentiation/immunology
MH  - Antigens, Neoplasm/immunology
MH  - Antigens, Surface/*analysis
MH  - Dipeptidyl Peptidase 4
MH  - Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/immunology
MH  - Fluorescent Antibody Technique
MH  - Glomerulonephritis/etiology/immunology
MH  - Glomerulonephritis, Membranous/etiology/*immunology
MH  - Humans
MH  - Kidney Glomerulus/*immunology
MH  - Mice
MH  - Microvilli/immunology
MH  - Neprilysin/immunology
MH  - Rabbits
MH  - Rats
RF  - 51
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PST - ppublish
SO  - Appl Pathol. 1989;7(2):85-98.