PMID- 25672988
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20150317
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 11
IP  - 6
DP  - 2015 Jun
TI  - Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord 
      injury.
PG  - 4262-6
LID - 10.3892/mmr.2015.3330 [doi]
AB  - Previous studies have suggested that impairment secondary to mechanical injury is 
      a major cause of irreversible damage to the spinal cord. Inflammatory chemokines 
      have been shown to play an important role in the pathological and physiological 
      consequences of secondary spinal cord injury (SCI). The aim of the present study 
      was to evaluate how changes in the expression levels of the cellular chemokine, 
      monocyte chemoattractant peptide-1 (MCP-1), and the chemotaxis of inflammatory 
      cells (monocytes and macrophages) are involved in the process of SCI. RNA 
      interference methods were used to study the mechanisms that protect residual 
      neurons after SCI in an attempt to explore novel, early interventions for 
      managing SCI. Our results suggested that inhibiting inflammation alleviates nerve 
      cell injury caused by apoptosis and provides a potentially important approach for 
      the future treatment of secondary SCI.
FAU - Zhang, Xuesong
AU  - Zhang X
AD  - Spine Department, General Hospital of PLA, Beijing 100853, P.R. China.
FAU - Chen, Chao
AU  - Chen C
AD  - Spine Department, General Hospital of PLA, Beijing 100853, P.R. China.
FAU - Ma, Shengzhong
AU  - Ma S
AD  - Spine Department, The Second Hospital of Shandong University, Jinan, Shandong 
      250033, P.R. China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Spine Department, General Hospital of PLA, Beijing 100853, P.R. China.
FAU - Zhang, Xuelian
AU  - Zhang X
AD  - Endocrine Department, China-Japan Friendship Hospital, Beijing 100029, P.R. 
      China.
FAU - Su, Xiaojing
AU  - Su X
AD  - Spine Department, General Hospital of PLA, Beijing 100853, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150211
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Small Interfering)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Animals
MH  - Apoptosis/genetics
MH  - Caspase 3/genetics/metabolism
MH  - Chemokine CCL2/*genetics
MH  - Gene Expression Regulation
MH  - Inflammation/genetics/pathology
MH  - Male
MH  - Neurons/metabolism/pathology
MH  - *RNA Interference
MH  - RNA, Messenger/genetics
MH  - RNA, Small Interfering/genetics
MH  - Rats
MH  - Spinal Cord Injuries/*genetics/pathology
EDAT- 2015/02/13 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/13 06:00
PHST- 2013/01/09 00:00 [received]
PHST- 2013/05/13 00:00 [accepted]
PHST- 2015/02/13 06:00 [entrez]
PHST- 2015/02/13 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.3892/mmr.2015.3330 [doi]
PST - ppublish
SO  - Mol Med Rep. 2015 Jun;11(6):4262-6. doi: 10.3892/mmr.2015.3330. Epub 2015 Feb 11.