PMID- 25673126
OWN - NLM
STAT- MEDLINE
DCOM- 20160108
LR  - 20181113
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 262
IP  - 4
DP  - 2015
TI  - Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by 
      cardiac magnetic resonance tomography.
PG  - 949-56
LID - 10.1007/s00415-014-7623-1 [doi]
AB  - The aim of this study was to investigate cardiac involvement in patients with 
      idiopathic inflammatory myopathies excluding inclusion body myositis with cardiac 
      magnetic resonance tomography (CMR). A case series of 53 patients with 
      polymyositis, dermatomyositis, or non-specific myositis underwent CMR including 
      functional imaging, T1-weighted, and late gadolinium enhancement (LGE) imaging. 
      T1-weighted and LGE images were analyzed for myocardial enhancement. Reduced left 
      ventricular function (LVF) was found in 9 (7%) patients. Patients with reduced 
      LVF more often presented with early and late myocardial enhancement (p = 0.014 
      and p = 0.001). In 33 (62.3%) patients, LGE was observed by CMR. These patients 
      had significantly lower left ventricular ejection fractions (p < 0.001) compared 
      to patients without LGE. LGE was mainly present in the lateral (p < 0.01) and 
      inferior (p < 0.02) segments. No correlations of LGE presence or reduced LVF to 
      cardiovascular risk factors were found. Myocardial inflammation is very frequent 
      in polymyositis, dermatomyositis, and non-specific myositis. In our patient, 
      cohort CMR demonstrated signs of myocardial inflammation in 62.3%. CMR seems to 
      offer a measurable and quantifiable diagnostic tool for cardiac involvement of 
      idiopathic inflammatory myopathies and can thus be used to monitor disease 
      progress and therapeutic success in these patients.
FAU - Rosenbohm, Angela
AU  - Rosenbohm A
AD  - Department of Neurology, University of Ulm, Ulm, Germany.
FAU - Buckert, Dominik
AU  - Buckert D
FAU - Gerischer, Nora
AU  - Gerischer N
FAU - Walcher, Thomas
AU  - Walcher T
FAU - Kassubek, Jan
AU  - Kassubek J
FAU - Rottbauer, Wolfgang
AU  - Rottbauer W
FAU - Ludolph, Albert C
AU  - Ludolph AC
FAU - Bernhardt, Peter
AU  - Bernhardt P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150212
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - AU0V1LM3JT (Gadolinium)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
SB  - IM
MH  - Adenosine Triphosphatases/metabolism
MH  - Creatine Kinase/blood
MH  - *Early Diagnosis
MH  - Electron Transport Complex IV/metabolism
MH  - Female
MH  - Gadolinium/metabolism
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/metabolism/pathology
MH  - Myocardium/*pathology
MH  - Myositis/blood/*diagnosis
MH  - Natriuretic Peptide, Brain/metabolism
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Succinate Dehydrogenase/metabolism
MH  - Tomography, X-Ray Computed
EDAT- 2015/02/13 06:00
MHDA- 2016/01/09 06:00
CRDT- 2015/02/13 06:00
PHST- 2014/09/11 00:00 [received]
PHST- 2014/12/20 00:00 [accepted]
PHST- 2014/12/19 00:00 [revised]
PHST- 2015/02/13 06:00 [entrez]
PHST- 2015/02/13 06:00 [pubmed]
PHST- 2016/01/09 06:00 [medline]
AID - 10.1007/s00415-014-7623-1 [doi]
PST - ppublish
SO  - J Neurol. 2015;262(4):949-56. doi: 10.1007/s00415-014-7623-1. Epub 2015 Feb 12.