PMID- 25673192
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20181113
IS  - 1672-0733 (Print)
IS  - 1672-0733 (Linking)
VI  - 35
IP  - 1
DP  - 2015 Feb
TI  - Clinicopathological features of renal amyloidosis: a single-center study on 47 
      cases.
PG  - 48-53
LID - 10.1007/s11596-015-1387-4 [doi]
AB  - The correlations between the clinicopathological features and the long-term 
      outcomes of renal amyloidosis (RA) were analyzed with a view to develop 
      strategies for improving diagnosis and prognosis of RA. We retrospectively 
      reviewed the clinicopathological characteristics of 47 patients diagnosed with RA 
      between 2004 and 2014 at the Wuhan Union Hospital. The data on the renal 
      histology, clinical manifestations, and prognosis of RA patients were retrieved 
      from the hospital records and characteristic patterns were identified. The 
      histological changes in the kidneys were correlated with the clinical 
      manifestations of RA. Additionally, most RA patients in this study had decreased 
      serum levels of kappa light chain and increased urine levels of kappa and lambda light chains 
      as well as presence of M-protein in the urine and serum. Patients with early RA 
      showed no specific pathognomonic symptoms. Bleeding associated with diagnostic 
      renal biopsy was rare. We recommend that the routine work-up of patients aged 
      over 40 years and presenting with non-diabetic nephropathy includes the 
      non-invasive tests for the measurement of serum and urine levels of kappa and lambda light 
      chains as well as protein electrophoresis tests for the presence of urinary and 
      serum M-protein. Additionally, such patients should undergo renal biopsy 
      screening with Cong-red staining to ensure early diagnosis of RA and improve 
      their survival, since the risk of hemorrhage related to renal biopsy screening is 
      low at early stages of RA.
FAU - Luo, Chang-Qing
AU  - Luo CQ
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Zhang, Yu-An
AU  - Zhang YA
AD  - Department of Nephrology, The Third People's Hospital of Yunnan Province, 
      Kunming, 650011, China.
FAU - Li, Zhen-Qiong
AU  - Li ZQ
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Wang, Yu-Mei
AU  - Wang YM
AD  - Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China. wangyumei75@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150212
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Amyloidosis/diagnosis/*pathology
MH  - Biopsy
MH  - Humans
MH  - Immunoglobulins/blood/urine
MH  - Kidney Diseases/diagnosis/*pathology
MH  - Prognosis
EDAT- 2015/02/13 06:00
MHDA- 2015/07/03 06:00
CRDT- 2015/02/13 06:00
PHST- 2014/08/29 00:00 [received]
PHST- 2014/10/25 00:00 [revised]
PHST- 2015/02/13 06:00 [entrez]
PHST- 2015/02/13 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
AID - 10.1007/s11596-015-1387-4 [pii]
AID - 10.1007/s11596-015-1387-4 [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2015 Feb;35(1):48-53. doi: 
      10.1007/s11596-015-1387-4. Epub 2015 Feb 12.