PMID- 25673459
OWN - NLM
STAT- MEDLINE
DCOM- 20150928
LR  - 20221207
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 128
IP  - 4
DP  - 2015 Feb 20
TI  - Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a 
      on susceptibility to type 2 diabetes mellitus in Chinese Han people.
PG  - 533-9
LID - 10.4103/0366-6999.151112 [doi]
AB  - BACKGROUND: Polymorphisms of microRNA (miRNA), as a novel mechanism, are closely 
      associated with disease states by interfering with miRNA function. Direct 
      correlations have been identified between single-nucleotide polymorphisms (SNPs) 
      in miRNA, but the effect on type 2 diabetes mellitus (T2DM) onset among Chinese 
      population remains unclear. Therefore, the aim of this study was to identify 
      correlations between common SNPs in miR-27a, miR-146a, and miR-124a with T2DM 
      among a Chinese population, as well as to explore diabetic pathological 
      mechanisms and the impact of environmental factors. METHODS: SNPscan technology 
      was used to genotype 995 patients newly diagnosed with T2DM and 967 controls. 
      Logistic regression analysis was performed to compare mutation frequencies 
      between cases and controls. RESULTS: We found no significant correlations between 
      all genotypes of these miRNAs and T2DM in our research. However, stratification 
      analysis identified a lower risk of T2DM associated with the rs531564GC genotype 
      among younger subjects (age < 45 years) (adjusted P = 0.043; odds ratio [OR] = 
      0.73; 95% confidence interval [CI] = 0.54-0.99). Furthermore, the rs895819CC 
      genotype in overweight people (24 </= body mass index [BMI] < 28) was significantly 
      associated with an increased risk of T2DM (adjusted P = 0.042; OR = 1.73; 95% CI 
      = 1.02-2.94), while the rs2910164 genotype in miR-146a was not significantly 
      correlated with T2DM. The genetic risk score was calculated based on the number 
      of risk alleles of the three SNPs and was found to be correlated to total 
      cholesterol (adjusted P = 0.021). CONCLUSIONS: The rs531564GC genotype acted as a 
      protective factor to decrease the risk of T2DM in younger subjects (age < 45 
      years), while the presence of the rs895819CC genotype increased the risk of 
      illness among overweight subjects (24 </= BMI < 28 kg/m 2 ). The presence of SNPs 
      in miRNA might promote disease by affecting miRNA expression and gene function. 
      Thus, miRNA mimics or inhibitors that directly regulate miRNA expression present 
      novel and promising therapeutic targets.
FAU - Wang, Tong-Tong
AU  - Wang TT
FAU - Chen, Yong-Jie
AU  - Chen YJ
FAU - Sun, Lu-Lu
AU  - Sun LL
FAU - Zhang, Si-Jia
AU  - Zhang SJ
FAU - Zhou, Zhong-Yu
AU  - Zhou ZY
FAU - Qiao, Hong
AU  - Qiao H
AD  - Department of Endemic Disease, The Second Affiliated Hospital, Harbin Medical 
      University, Harbin, Heilongjiang 150081, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (MIRN124 microRNA, human)
RN  - 0 (MIRN146 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Young Adult
PMC - PMC4836260
COIS- Conflict of Interest: None declared.
EDAT- 2015/02/13 06:00
MHDA- 2015/09/29 06:00
PMCR- 2015/02/20
CRDT- 2015/02/13 06:00
PHST- 2015/02/13 06:00 [entrez]
PHST- 2015/02/13 06:00 [pubmed]
PHST- 2015/09/29 06:00 [medline]
PHST- 2015/02/20 00:00 [pmc-release]
AID - ChinMedJ_2015_128_4_533_151112 [pii]
AID - CMJ-128-533 [pii]
AID - 10.4103/0366-6999.151112 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2015 Feb 20;128(4):533-9. doi: 10.4103/0366-6999.151112.