PMID- 25674259
OWN - NLM
STAT- MEDLINE
DCOM- 20151030
LR  - 20220316
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 7
IP  - 12
DP  - 2014
TI  - LncRNA HMlincRNA717 is down-regulated in non-small cell lung cancer and 
      associated with poor prognosis.
PG  - 8881-6
AB  - INTRODUCTION: Long non coding RNAs (lncRNAs) have emerged recently as major 
      players in tumor biology and may be used for cancer diagnosis, prognosis, and 
      potential therapeutic targets. The lncRNA HMlincRNA717, a newly identified 
      lncRNA, was demonstrated to be down-regulated in gastric cancer. However, little 
      is known about its role in non small cell lung cancer (NSCLC). METHODS: 
      Expression of lncRNA HMlincRNA717 in tumor and their matched non-tumor tissues 
      was determined by quantitative real-time PCR (qRT-PCR) in NSCLC patients. Then, 
      we analyzed the potential relationship between lncRNA HMlincRNA717 expression 
      levels in tumor tissues and clinicopathological features of NSCLC, and clinical 
      outcome. RESULTS: lncRNA HMlincRNA717 expression level was significantly 
      decreased in NSCLC tissues in comparison to adjacent non-tumor tissues. It was 
      also proved that HMlincRNA717 expression was to be associated with NSCLC 
      histological grade, and lymph node metastasis. In addition, survival analysis 
      proved that down-regulated HMlincRNA717 expression was associated with poor 
      overall survival of NSCLC patients. Multivariate survival analysis also proved 
      that HMlincRNA717 was an independent prognostic factor for NSCLC patients. 
      CONCLUSIONS: The present study showed the down-regulation of HMlincRNA717 and its 
      association with tumor progression in human NSCLC. It also provided that 
      HMlincRNA717 expression was an independent prognostic factor for patients with 
      NSCLC, which might be a potential prognostic biomarker and therapeutic target for 
      NSCLC.
FAU - Xie, Xiao
AU  - Xie X
AD  - Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai 
      Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
FAU - Liu, Hong-Tao
AU  - Liu HT
AD  - Department of Cardio-thoracic Surgery, The First Affiliated Hospital of Soochow 
      University Suzhou 215006, P. R. China.
FAU - Mei, Ju
AU  - Mei J
AD  - Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai 
      Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
FAU - Ding, Fang-Bao
AU  - Ding FB
AD  - Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai 
      Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
FAU - Xiao, Hai-Bo
AU  - Xiao HB
AD  - Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai 
      Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
FAU - Hu, Feng-Qing
AU  - Hu FQ
AD  - Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai 
      Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
FAU - Hu, Rui
AU  - Hu R
AD  - Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai 
      Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
FAU - Wang, Ming-Song
AU  - Wang MS
AD  - Department of Cardio-thoracic Surgery, Xin Hua Hospital Affiliated to Shanghai 
      Jiao Tong University School of Medicine Shanghai 200092, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20141201
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Non-Small-Cell Lung/metabolism/mortality/*pathology
MH  - Down-Regulation
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/metabolism/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - RNA, Long Noncoding/*biosynthesis
MH  - Real-Time Polymerase Chain Reaction
PMC - PMC4314049
OTO - NOTNLM
OT  - HMlincRNA717
OT  - Long non coding RNA
OT  - non small cell lung cancer
OT  - prognosis
EDAT- 2015/02/13 06:00
MHDA- 2015/10/31 06:00
PMCR- 2014/12/01
CRDT- 2015/02/13 06:00
PHST- 2014/09/28 00:00 [received]
PHST- 2014/11/26 00:00 [accepted]
PHST- 2015/02/13 06:00 [entrez]
PHST- 2015/02/13 06:00 [pubmed]
PHST- 2015/10/31 06:00 [medline]
PHST- 2014/12/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2014 Dec 1;7(12):8881-6. eCollection 2014.