PMID- 2567491
OWN - NLM
STAT- MEDLINE
DCOM- 19890717
LR  - 20071114
IS  - 0885-3185 (Print)
IS  - 0885-3185 (Linking)
VI  - 4
IP  - 2
DP  - 1989
TI  - HLA antigens in drug-induced parkinsonism.
PG  - 121-8
AB  - The results of two epidemiological studies suggest a hereditary predisposition to 
      develop drug-induced parkinsonism. We investigated human leukocyte antigen (HLA) 
      antigen prevalence rates in patients with neuroleptic-induced parkinsonism. 
      Fifty-two male, white, neuroleptic-treated, chronic in-patients with 
      DSM-III-diagnosed schizophrenia were examined for the presence of parkinsonism. 
      Subjects were tested for 23 type A, 43 type B, 4 type C, and 10 type DR HLA 
      antigens. The group of schizophrenic patients with parkinsonism (n = 29) was 
      compared with the group of schizophrenic patients without parkinsonism (n = 23). 
      There were no significant differences between the two groups with respect to age, 
      duration of neuroleptic exposure, or anticholinergic drug exposure. One HLA 
      antigen, B44, was significantly more prevalent in the group with parkinsonism 
      than in the group without parkinsonism. We derived a relative risk of 7.16 for 
      drug-induced parkinsonism with HLA-B44 present in this group of schizophrenic 
      patients. These data indicate that HLA-B44 may play a role in genetic or 
      immunologic susceptibility to develop drug-induced parkinsonism in white 
      schizophrenic individuals.
FAU - Metzer, W S
AU  - Metzer WS
AD  - Department of Neurology, University of Arkansas for Medical Sciences, Little 
      Rock.
FAU - Newton, J E
AU  - Newton JE
FAU - Steele, R W
AU  - Steele RW
FAU - Claybrook, M
AU  - Claybrook M
FAU - Paige, S R
AU  - Paige SR
FAU - McMillan, D E
AU  - McMillan DE
FAU - Hays, S
AU  - Hays S
LA  - eng
GR  - RR05350-23/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (Antipsychotic Agents)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*adverse effects/therapeutic use
MH  - Dyskinesia, Drug-Induced/*genetics
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Parkinson Disease, Secondary/*chemically induced/genetics
MH  - Risk Factors
MH  - Schizophrenia/*drug therapy/genetics
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1002/mds.870040203 [doi]
PST - ppublish
SO  - Mov Disord. 1989;4(2):121-8. doi: 10.1002/mds.870040203.