PMID- 25675140
OWN - NLM
STAT- MEDLINE
DCOM- 20160127
LR  - 20150508
IS  - 1557-8976 (Electronic)
IS  - 0882-8245 (Linking)
VI  - 28
IP  - 4
DP  - 2015 May
TI  - Pathological evaluation of reproductive system of porcine reproductive and 
      respiratory syndrome virus-vaccinated and nonvaccinated anestrus sows and gilts.
PG  - 229-35
LID - 10.1089/vim.2014.0138 [doi]
AB  - The purpose of the study was to evaluate pathologically the reproductive system 
      of nonvaccinated and porcine reproductive and respiratory syndrome virus 
      (PRRSV)-vaccinated sows/gilts, as well as the assessment of vaccination impact on 
      their endometrium/myometrium and ovaries. In a farrow-to-finish farm, all sows 
      and gilts were systematically vaccinated with a PRRSV-inactivated vaccine for a 
      period of 18 months. During the last semester before the beginning of the trial, 
      the genital organs (uterus and ovaries) from 50 females (nonvaccinated 
      primiparous and multiparous sows that did not exhibit signs of estrus until 10 
      days post-weaning) were collected at the slaughterhouse for gross and microscopic 
      examination (parity 1 to >6). Respectively, during the following three semesters 
      after the implementation of the experimental PRRSV vaccination scheme, the 
      genital organs from 75 vaccinated sows-25 samples taken along the period of each 
      semester-were also collected. Gross examinations included measurements of uterine 
      horn (thickness and diameter) and ovaries (diameter). Microscopic examination 
      focused on histopathological examination of ovarian cysts or other cystic 
      formations and evaluation of the endometrium and myometrium. Measurements of 
      uterine horn's thickness/diameter and ovaries' diameter were at normal levels, 
      and no significant differences were found on gross examination between vaccinated 
      and nonvaccinated females. The results of histopathological examinations did not 
      show lesions of endometritis or myometritis, but revealed ovarian cystic 
      formations with a diameter of >2 cm that were luteinizing cysts. The presence of 
      these luteinizing cysts was significantly lower in PRRSV-vaccinated animals, 
      compared to nonvaccinated, three semesters (p=0.017) after the start of 
      vaccinations and for the total trial period (p=0.009).
FAU - Papatsiros, Vasileios
AU  - Papatsiros V
AD  - 1 Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly , 
      Karditsa, Greece .
FAU - Psalla, Dimitra
AU  - Psalla D
FAU - Papaioannou, Dimitrios
AU  - Papaioannou D
FAU - Tassis, Panagiotis
AU  - Tassis P
FAU - Tzika, Eleni
AU  - Tzika E
FAU - Papaioannou, Nikolaos
AU  - Papaioannou N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150212
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (Vaccines, Inactivated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Anestrus
MH  - Animals
MH  - Biometry
MH  - Biostatistics
MH  - Endometrium/*pathology
MH  - Female
MH  - Myometrium/*pathology
MH  - Ovary/*pathology
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - Vaccines, Inactivated/administration & dosage
MH  - Viral Vaccines/*administration & dosage
EDAT- 2015/02/13 06:00
MHDA- 2016/01/28 06:00
CRDT- 2015/02/13 06:00
PHST- 2015/02/13 06:00 [entrez]
PHST- 2015/02/13 06:00 [pubmed]
PHST- 2016/01/28 06:00 [medline]
AID - 10.1089/vim.2014.0138 [doi]
PST - ppublish
SO  - Viral Immunol. 2015 May;28(4):229-35. doi: 10.1089/vim.2014.0138. Epub 2015 Feb 
      12.