PMID- 25675182
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20211203
IS  - 1538-7151 (Electronic)
IS  - 0277-1691 (Linking)
VI  - 34
IP  - 2
DP  - 2015 Mar
TI  - NUT midline carcinoma presenting with bilateral ovarian metastases: a case 
      report.
PG  - 136-42
LID - 10.1097/PGP.0000000000000129 [doi]
AB  - Nuclear protein of the testis (NUT) midline carcinoma (NMC) is an uncommon, 
      relatively recently characterized carcinoma, which is defined by NUT gene 
      rearrangements. We are reporting a case of NMC in a 38-year-old female who 
      presented with pleural effusion and bilateral ovarian masses. We also discuss 
      some of the difficulties encountered by the practicing pathologist in reaching 
      the diagnosis and the role of ancillary studies. Immunohistochemical staining 
      using a commercially available monoclonal antibody showing nuclear expression of 
      the NUT protein is diagnostic of NMC. Dual-color split-apart fluorescence in situ 
      hybridization (FISH) or reverse transcription polymerase chain reaction (RT-PCR) 
      can be used to characterize the fusion gene, whether BRD4-NUT or BRD3-NUT, or 
      NUT-variant.
FAU - Dragoescu, Ema
AU  - Dragoescu E
AD  - Department of Pathology (E.D.) Department of Surgery, Division of Cardiothoracic 
      Surgery (A.C.) Department of Internal Medicine, Division of Hematology, Oncology 
      and Palliative Care (S.B.) Department of Obstetrics and Gynecology, Division of 
      Gynecologic Oncology (W.C.), VCU Health System, Richmond, Virginia Department of 
      Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, 
      Massachusetts (C.F.).
FAU - French, Christopher
AU  - French C
FAU - Cassano, Anthony
AU  - Cassano A
FAU - Baker, Sherman Jr
AU  - Baker S Jr
FAU - Chafe, Weldon
AU  - Chafe W
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Gynecol Pathol
JT  - International journal of gynecological pathology : official journal of the 
      International Society of Gynecological Pathologists
JID - 8214845
RN  - 0 (NUTM1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Carcinoma/*secondary
MH  - Female
MH  - Humans
MH  - Mediastinal Neoplasms/*pathology
MH  - Neoplasm Proteins
MH  - Nuclear Proteins/*genetics
MH  - Oncogene Proteins/*genetics
MH  - Ovarian Neoplasms/*secondary
EDAT- 2015/02/13 06:00
MHDA- 2015/11/18 06:00
CRDT- 2015/02/13 06:00
PHST- 2015/02/13 06:00 [entrez]
PHST- 2015/02/13 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 00004347-201503000-00006 [pii]
AID - 10.1097/PGP.0000000000000129 [doi]
PST - ppublish
SO  - Int J Gynecol Pathol. 2015 Mar;34(2):136-42. doi: 10.1097/PGP.0000000000000129.