PMID- 25675278
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20150303
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 140
IP  - 6
DP  - 2015 Mar 21
TI  - Polar organic solvents accelerate the rate of DNA strand replacement reaction.
PG  - 2023-8
LID - 10.1039/c4an02302a [doi]
AB  - Herein, we report a novel strategy to accelerate the rate of DNA strand 
      replacement reaction (DSRR) by polar organic solvents. DSRR plays a vital role in 
      DNA nanotechnology but prolonged reaction time limits its further advancement. 
      That is why it is extremely important to speed up the rate of DSRR. In this work, 
      we introduce different polar organic solvents in both simple and complicated DSRR 
      systems and observe that the rate constant is much more than in aqueous buffer. 
      The rate acceleration of DSRR by polar organic solvents is very obvious and we 
      believe that this strategy will extend the application of DNA nanotechnology in 
      future.
FAU - Zhang, Tianchi
AU  - Zhang T
AD  - Key Laboratory for Large-Format Battery Materials and System, Ministry of 
      Education, School of Chemistry and Chemical Engineering, Huazhong University of 
      Science and Technology, Wuhan 430074, China. xiafan@hust.edu.cn.
FAU - Shang, Chunli
AU  - Shang C
FAU - Duan, Ruixue
AU  - Duan R
FAU - Hakeem, Abdul
AU  - Hakeem A
FAU - Zhang, Zhenyu
AU  - Zhang Z
FAU - Lou, Xiaoding
AU  - Lou X
FAU - Xia, Fan
AU  - Xia F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Organic Chemicals)
RN  - 0 (Solvents)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/*chemistry
MH  - Nanotechnology
MH  - Nucleic Acid Conformation
MH  - Organic Chemicals/chemistry
MH  - Solvents/*chemistry
MH  - Spectrometry, Fluorescence
EDAT- 2015/02/13 06:00
MHDA- 2015/09/22 06:00
CRDT- 2015/02/13 06:00
PHST- 2015/02/13 06:00 [entrez]
PHST- 2015/02/13 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
AID - 10.1039/c4an02302a [doi]
PST - ppublish
SO  - Analyst. 2015 Mar 21;140(6):2023-8. doi: 10.1039/c4an02302a.