PMID- 25675901 OWN - NLM STAT- MEDLINE DCOM- 20160113 LR - 20160225 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 183 DP - 2015 Mar 15 TI - Prediction of functional recovery by cardiac magnetic resonance feature tracking imaging in first time ST-elevation myocardial infarction. Comparison to infarct size and transmurality by late gadolinium enhancement. PG - 162-70 LID - S0167-5273(15)00047-9 [pii] LID - 10.1016/j.ijcard.2015.01.022 [doi] AB - PURPOSE: To investigate whether myocardial deformation imaging, assessed by feature tracking cardiac magnetic resonance (FTI-CMR), would allow objective quantification of myocardial strain and estimation of functional recovery in patients with first time ST-elevation myocardial infarction (STEMI). METHODS: Cardiac magnetic resonance (CMR) imaging was performed in 74 consecutive patients 2-4 days after successfully reperfused STEMI, using a 1.5T CMR scanner (Philips Achieva). Peak systolic circumferential and longitudinal strains were measured using the FTI applied to SSFP cine sequences and were compared to infarct size, determined by late gadolinium enhancement (LGE). Follow-up CMR at 6 months was performed in order to assess residual ejection fraction, which deemed as the reference standard for the estimation of functional recovery. RESULTS: During the follow-up period 53 of 74 (72%) patients exhibited preserved residual ejection fraction >/=50%. A cut-off value of -19.3% for global circumferential strain identified patients with preserved ejection fraction >/=50% at follow-up with sensitivity of 76% and specificity of 85% (AUC=0.86, 95% CI=0.75-0.93, p<0.001), which was superior to that provided by longitudinal strain (DeltaAUC=0.13, SE=0.05, z-statistic=2.5, p=0.01), and non-inferior to that provided by LGE (DeltaAUC=0.07, p=NS). Multivariate analysis showed that global circumferential strain and LGE exhibited independent value for the prediction of preserved LV-function, surpassing that provided by age, diabetes and baseline ejection fraction (HR=1.4, 95% CI=1.0-1.9 and HR=1.4, 95% CI=1.1-1.7, respectively, p<0.05 for both). CONCLUSIONS: Estimation of circumferential strain by FTI provides objective assessment of infarct size without the need for contrast agent administration and estimation of functional recovery with non-inferior accuracy compared to that provided by LGE. CI - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved. FAU - Buss, Sebastian J AU - Buss SJ AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Krautz, Birgit AU - Krautz B AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Hofmann, Nina AU - Hofmann N AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Sander, Yannick AU - Sander Y AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Rust, Lukas AU - Rust L AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Giusca, Sorin AU - Giusca S AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Galuschky, Christian AU - Galuschky C AD - TomTec Imaging Systems GmbH, Munich, Germany. FAU - Seitz, Sebastian AU - Seitz S AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Giannitsis, Evangelos AU - Giannitsis E AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Pleger, Sven AU - Pleger S AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Raake, Philip AU - Raake P AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Most, Patrick AU - Most P AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Katus, Hugo A AU - Katus HA AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. FAU - Korosoglou, Grigorios AU - Korosoglou G AD - Department of Cardiology, University of Heidelberg, INF 410, 69120 Heidelberg, Germany. Electronic address: grigorios.korosoglou@med.uni-heidelberg.de. LA - eng PT - Comparative Study PT - Journal Article DEP - 20150107 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 RN - 0 (Contrast Media) RN - 0 (Troponin T) RN - AU0V1LM3JT (Gadolinium) SB - IM CIN - Int J Cardiol. 2015 May 1;186:202-3. PMID: 25828114 CIN - Int J Cardiol. 2016 Jan 1;202:799. PMID: 26476033 MH - Aged MH - Contrast Media MH - Electrocardiography/methods MH - Female MH - Gadolinium MH - Humans MH - Image Enhancement/*methods MH - Image Interpretation, Computer-Assisted MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Myocardial Infarction/diagnosis/*physiopathology MH - ROC Curve MH - Recovery of Function MH - Sensitivity and Specificity MH - Stroke Volume/physiology MH - Troponin T/analysis MH - Ventricular Function, Left/physiology OTO - NOTNLM OT - Cardiac magnetic resonance OT - FTI OT - Late gadolinium enhancement OT - Left ventricular function OT - Myocardial infarction OT - STEMI OT - Two dimensional strain imaging EDAT- 2015/02/14 06:00 MHDA- 2016/01/14 06:00 CRDT- 2015/02/14 06:00 PHST- 2014/10/14 00:00 [received] PHST- 2014/12/23 00:00 [revised] PHST- 2015/01/04 00:00 [accepted] PHST- 2015/02/14 06:00 [entrez] PHST- 2015/02/14 06:00 [pubmed] PHST- 2016/01/14 06:00 [medline] AID - S0167-5273(15)00047-9 [pii] AID - 10.1016/j.ijcard.2015.01.022 [doi] PST - ppublish SO - Int J Cardiol. 2015 Mar 15;183:162-70. doi: 10.1016/j.ijcard.2015.01.022. Epub 2015 Jan 7.