PMID- 25675999
OWN - NLM
STAT- MEDLINE
DCOM- 20150602
LR  - 20150326
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Linking)
VI  - 35
IP  - 4
DP  - 2015 Apr
TI  - Dendritic cells in atherosclerosis: evidence in mice and humans.
PG  - 763-70
LID - 10.1161/ATVBAHA.114.303566 [doi]
AB  - Atherosclerotic vascular disease is driven by chronic inflammation involving both 
      innate and adaptive immune responses. Dendritic cells (DCs) are found in healthy 
      arteries and accumulate in atherosclerotic lesions and engage in diverse 
      pathogenic and protective mechanisms during atherogenesis. DCs contribute to 
      early foam cell formation, regulate lipid metabolism, and control pro- and 
      antiatherosclerotic T-cell responses by multifarious mechanisms. We, here, review 
      the roles of DCs and plasmacytoid DCs in experimental models of atherosclerosis 
      and the approaches to target DCs in therapeutic vaccination strategies. We, 
      furthermore, discuss the evidence of the potential function of DCs in human 
      atherosclerosis, and dissect the efforts to harness DC subsets as biomarkers of 
      disease. Finally, we discuss necessary future steps that will help to understand 
      the specific contribution of bona fide DCs in atherosclerosis to move toward 
      novel therapeutic approaches.
CI  - (c) 2015 American Heart Association, Inc.
FAU - Zernecke, Alma
AU  - Zernecke A
AD  - From the Institute of Clinical Biochemistry and Pathobiochemistry, University 
      Hospital Wurzburg, Wurzburg, Germany. alma.zernecke@uni-wuerzburg.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150212
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
SB  - IM
MH  - Adoptive Transfer/methods
MH  - Animals
MH  - Arteries/*immunology/metabolism/pathology
MH  - Atherosclerosis/*immunology/metabolism/pathology/therapy
MH  - Cell Movement
MH  - Dendritic Cells/classification/*immunology/metabolism/transplantation
MH  - Foam Cells/immunology/metabolism
MH  - Humans
MH  - Lipid Metabolism
MH  - Lymphocyte Activation
MH  - Mice
MH  - Plaque, Atherosclerotic
MH  - Signal Transduction
MH  - T-Lymphocytes/immunology/metabolism
OTO - NOTNLM
OT  - atherosclerosis
OT  - dendritc cells
OT  - humans
OT  - immune system
OT  - inflammation
OT  - leukocytes
OT  - mice
EDAT- 2015/02/14 06:00
MHDA- 2015/06/03 06:00
CRDT- 2015/02/14 06:00
PHST- 2015/02/14 06:00 [entrez]
PHST- 2015/02/14 06:00 [pubmed]
PHST- 2015/06/03 06:00 [medline]
AID - ATVBAHA.114.303566 [pii]
AID - 10.1161/ATVBAHA.114.303566 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):763-70. doi: 
      10.1161/ATVBAHA.114.303566. Epub 2015 Feb 12.