PMID- 25679774
OWN - NLM
STAT- MEDLINE
DCOM- 20150504
LR  - 20150309
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 137
DP  - 2015 Feb
TI  - Significant accumulation of persistent organic pollutants and dysregulation in 
      multiple DNA damage repair pathways in the electronic-waste-exposed populations.
PG  - 458-66
LID - S0013-9351(14)00433-2 [pii]
LID - 10.1016/j.envres.2014.11.018 [doi]
AB  - Electronic waste (e-waste) has created a worldwide environmental and health 
      problem, by generating a diverse group of hazardous compounds such as persistent 
      organic pollutants (POPs). Our previous studies demonstrated that populations 
      from e-waste exposed region have a significantly higher level of chromosomal 
      aberrancy and incidence of DNA damage. In this study, we further demonstrated 
      that various POPs persisted at a significantly higher concentration in the 
      exposed group than those in the unexposed group. The level of reactive oxygen 
      species and micronucleus rate were also significantly elevated in the exposed 
      group. RNA sequencing analysis revealed 31 genes in DNA damage responses and 
      repair pathways that were differentially expressed between the two groups (Log2 
      ratio >1 or <-1). Our data demonstrated that both females and males of the 
      exposed group have activated a series of DNA damage response genes; however many 
      important DNA repair pathways have been dysregulated. Expressions of NEIL1/3 and 
      RPA3, which are critical in initiating base pair and nucleotide excision repairs 
      respectively, have been downregulated in both females and males of the exposed 
      group. In contrast, expression of RNF8, an E3 ligase involved in an error prone 
      non-homologous end joining repair for DNA double strand break, was upregulated in 
      both genders of the exposed group. The other genes appeared to be differentially 
      expressed only when the males or females of the two groups were compared 
      respectively. Importantly, the expression of cell cycle regulatory gene CDC25A 
      that has been implicated in multiple kinds of malignant transformation was 
      significantly upregulated among the exposed males while downregulated among the 
      exposed females. In conclusion, our studies have demonstrated significant 
      correlations between e-waste disposing and POPs accumulation, DNA lesions and 
      dysregulation of multiple DNA damage repair mechanisms in the residents of the 
      e-waste exposed region.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - He, Xiaobo
AU  - He X
AD  - Basic Medical College, Tianjin Medical University, Tianjin 300070, PR China.
FAU - Jing, Yaqing
AU  - Jing Y
AD  - Basic Medical College, Tianjin Medical University, Tianjin 300070, PR China.
FAU - Wang, Jianhai
AU  - Wang J
AD  - Basic Medical College, Tianjin Medical University, Tianjin 300070, PR China.
FAU - Li, Keqiu
AU  - Li K
AD  - Basic Medical College, Tianjin Medical University, Tianjin 300070, PR China.
FAU - Yang, Qiaoyun
AU  - Yang Q
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Tianjin Medical University, Tianjin 300070, PR China.
FAU - Zhao, Yuxia
AU  - Zhao Y
AD  - Basic Medical College, Tianjin Medical University, Tianjin 300070, PR China.
FAU - Li, Ran
AU  - Li R
AD  - State Key Joint Laboratory for Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering and Center for Environment and 
      Health, Peking University, Beijing 100871, PR China.
FAU - Ge, Jie
AU  - Ge J
AD  - Department of Breast Surgery, Tianjin Medical University Cancer Institute and 
      Hospital, Tianjin 300060, PR China; Key Laboratory of Breast Cancer Prevention 
      and Treatment of the Ministry of Education, Tianjin Medical University Cancer 
      Institute and Hospital, Tianjin 300060, PR China.
FAU - Qiu, Xinghua
AU  - Qiu X
AD  - State Key Joint Laboratory for Environmental Simulation and Pollution Control, 
      College of Environmental Sciences and Engineering and Center for Environment and 
      Health, Peking University, Beijing 100871, PR China. Electronic address: 
      xhqiu@pku.edu.cn.
FAU - Li, Guang
AU  - Li G
AD  - Basic Medical College, Tianjin Medical University, Tianjin 300070, PR China. 
      Electronic address: lig@tijmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150211
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - China
MH  - DNA Damage/*drug effects
MH  - Electronic Waste/*adverse effects
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - *Refuse Disposal
MH  - Sequence Analysis, RNA
OTO - NOTNLM
OT  - POPs-induced DNA damage response
OT  - Persistent organic pollutants (POPs)
EDAT- 2015/02/14 06:00
MHDA- 2015/05/06 06:00
CRDT- 2015/02/14 06:00
PHST- 2014/08/13 00:00 [received]
PHST- 2014/11/10 00:00 [revised]
PHST- 2014/11/13 00:00 [accepted]
PHST- 2015/02/14 06:00 [entrez]
PHST- 2015/02/14 06:00 [pubmed]
PHST- 2015/05/06 06:00 [medline]
AID - S0013-9351(14)00433-2 [pii]
AID - 10.1016/j.envres.2014.11.018 [doi]
PST - ppublish
SO  - Environ Res. 2015 Feb;137:458-66. doi: 10.1016/j.envres.2014.11.018. Epub 2015 
      Feb 11.