PMID- 25681004
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20220330
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 226
IP  - 1
DP  - 2015 Mar 30
TI  - Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people 
      with schizophrenia: a meta-analysis.
PG  - 1-13
LID - S0165-1781(15)00055-4 [pii]
LID - 10.1016/j.psychres.2014.12.069 [doi]
AB  - Studies suggest that the BDNF Val66Met (rs6265) polymorphism is associated with 
      the incidence of schizophrenia and neurocognitive functioning. These associations 
      appear to be however somewhat mixed. We conducted two separate meta-analyses to 
      investigate (1) the association between the Val66Met polymorphism and 
      neurocognition in people with schizophrenia and (2) the association between 
      peripheral expression of BDNF and neurocognitive phenotypes. For the first aim, 
      we identified 12 studies and 67 comparisons of Met allele carriers and Val 
      homozygotes. These comparisons included 1890 people with schizophrenia (men=1465, 
      women=553), of whom 972 were Met allele carriers and 918 were Val homozygotes. 
      For the second aim, we identified five studies and 25 correlations of peripheral 
      BDNF and neurocognitive scores. The meta-analysis for the second aim included 414 
      people with schizophrenia (men=292, women=170). First, we found non-significant 
      difference between the genotype groups on most neurocognitive domains. Second, 
      correlations between peripheral BDNF and neurocognitive phenotypes were minimal 
      but we obtained significant effects for the reasoning and problem-solving 
      domains; thus, higher levels of BDNF expression corresponded to better 
      performance on reasoning/problem-solving tasks. The meta-analyses did not 
      robustly establish an association between BDNF Val66Met polymorphism and 
      neurocognition in schizophrenia.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Ahmed, Anthony O
AU  - Ahmed AO
AD  - Department of Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Road, 
      White Plains, NY 10605, USA; Department of Psychiatry and Health Behavior, 
      Georgia Regents University, 997 Saint Sebastian Way, Augusta, GA 30912, USA. 
      Electronic address: aoa9001@med.cornell.edu.
FAU - Mantini, Andrew M
AU  - Mantini AM
AD  - Department of Psychiatry and Health Behavior, Georgia Regents University, 997 
      Saint Sebastian Way, Augusta, GA 30912, USA.
FAU - Fridberg, Daniel J
AU  - Fridberg DJ
AD  - Department of Psychiatry, University of Chicago, 5841 S. Maryland Avenue, 
      Chicago, IL 60637, USA.
FAU - Buckley, Peter F
AU  - Buckley PF
AD  - Department of Psychiatry and Health Behavior, Georgia Regents University, 997 
      Saint Sebastian Way, Augusta, GA 30912, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20150128
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition Disorders/*epidemiology/*genetics/psychology
MH  - Humans
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Schizophrenia/diagnosis/*epidemiology/*genetics
MH  - *Schizophrenic Psychology
OTO - NOTNLM
OT  - BDNF
OT  - Neurocognition
OT  - Schizophrenia
OT  - Val66Met
EDAT- 2015/02/15 06:00
MHDA- 2015/11/17 06:00
CRDT- 2015/02/15 06:00
PHST- 2014/03/16 00:00 [received]
PHST- 2014/12/15 00:00 [revised]
PHST- 2014/12/19 00:00 [accepted]
PHST- 2015/02/15 06:00 [entrez]
PHST- 2015/02/15 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - S0165-1781(15)00055-4 [pii]
AID - 10.1016/j.psychres.2014.12.069 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Mar 30;226(1):1-13. doi: 10.1016/j.psychres.2014.12.069. 
      Epub 2015 Jan 28.