PMID- 2568121
OWN - NLM
STAT- MEDLINE
DCOM- 19890818
LR  - 20190903
IS  - 0284-186X (Print)
IS  - 0284-186X (Linking)
VI  - 28
IP  - 3
DP  - 1989
TI  - Treatment of the pancreatic disease of multiple endocrine neoplasia type 1 (MEN 
      1).
PG  - 415-7
AB  - This review comprises an analysis of the treatment alternatives for pancreatic 
      tumours of the MEN 1 syndrome presently in use at the Surgical Endocrine Unit of 
      Sahlgrenska Hospital, Goteborg, Sweden. Patients with pancreatic tumours 
      localized by imaging studies are offered surgical excision. Otherwise the therapy 
      is individualized. Some patients with Zollinger-Ellison syndromes are managed 
      with medical antiulcer treatment, others are treated with total gastrectomy. MEN 
      1 patients with other syndromes, e.g. insulinomas, glucagonomas and VIPomas, are 
      offered surgery with the aim of tumour excision. Even noncurative excision might 
      benefit the management of these cases and possibly prolong life. Asymptomatic 
      patients with raised hormonal tumour markers in whom imaging studies have failed 
      to reveal any tumours, are continuously followed without treatment. The malignant 
      behaviour of the pancreatic tumours varies between different MEN 1 families. MEN 
      1 patients are considered for total pancreatectomy if they have multiple 
      malignant pancreatic tumours and if the pancreatic disease has caused high 
      morbidity and mortality in the family.
FAU - Tisell, L E
AU  - Tisell LE
AD  - Department of Surgery, University of Goteborg, Sweden.
FAU - Ahlman, H
AU  - Ahlman H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
SB  - IM
MH  - Adenoma, Islet Cell/genetics/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/diagnosis/genetics/*therapy
MH  - Pancreatic Neoplasms/genetics/*therapy
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.3109/02841868909111215 [doi]
PST - ppublish
SO  - Acta Oncol. 1989;28(3):415-7. doi: 10.3109/02841868909111215.