PMID- 25681448
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20220321
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 84
IP  - 11
DP  - 2015 Mar 17
TI  - Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 
      CONFIRM study.
PG  - 1145-52
LID - 10.1212/WNL.0000000000001360 [doi]
AB  - OBJECTIVE: To evaluate the effects of oral delayed-release dimethyl fumarate 
      (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, 
      atrophy, and magnetization transfer ratio (MTR) measures from the Comparator and 
      an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study. 
      METHODS: CONFIRM was a 2-year, placebo-controlled study of the efficacy and 
      safety of DMF 240 mg twice (BID) or 3 times daily (TID) in 1,417 patients with 
      relapsing-remitting multiple sclerosis (RRMS); subcutaneous glatiramer acetate 20 
      mg once daily was included as an active reference comparator. The number and 
      volume of T2-hyperintense, T1-hypointense, and gadolinium-enhancing (Gd+) 
      lesions, as well as whole brain volume and MTR, were assessed in 681 patients 
      (MRI cohort). RESULTS: DMF BID and TID produced significant and consistent 
      reductions vs placebo in the number of new or enlarging T2-hyperintense lesions 
      and new nonenhancing T1-hypointense lesions after 1 and 2 years of treatment and 
      in the number of Gd+ lesions at week 24, year 1, and year 2. Lesion volumes were 
      also significantly reduced. Reductions in brain atrophy and MTR changes with DMF 
      relative to placebo did not reach statistical significance. CONCLUSIONS: The 
      robust effects on MRI active lesion counts and total lesion volume in patients 
      with RRMS demonstrate the ability of DMF to exert beneficial effects on 
      inflammatory lesion activity in multiple sclerosis, and support DMF therapy as a 
      valuable new treatment option in RRMS. CLASSIFICATION OF EVIDENCE: This study 
      provides Class I evidence of reduction in brain lesion number and volume, as 
      assessed by MRI, over 2 years of delayed-release DMF treatment.
CI  - (c) 2015 American Academy of Neurology.
FAU - Miller, David H
AU  - Miller DH
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA. david.h.miller@ucl.ac.uk.
FAU - Fox, Robert J
AU  - Fox RJ
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Phillips, J Theodore
AU  - Phillips JT
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Hutchinson, Michael
AU  - Hutchinson M
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Havrdova, Eva
AU  - Havrdova E
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Kita, Mariko
AU  - Kita M
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Wheeler-Kingshott, Claudia A M
AU  - Wheeler-Kingshott CA
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Tozer, Daniel J
AU  - Tozer DJ
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - MacManus, David G
AU  - MacManus DG
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Yousry, Tarek A
AU  - Yousry TA
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Goodsell, Mary
AU  - Goodsell M
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Yang, Minhua
AU  - Yang M
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Zhang, Ray
AU  - Zhang R
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Viglietta, Vissia
AU  - Viglietta V
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
FAU - Dawson, Katherine T
AU  - Dawson KT
AD  - From the Departments of Neuroinflammation (D.H.M., C.A.M.W.-K., D.J.T., D.G.M.) 
      and Brain Repair and Rehabilitation (T.A.Y.), NMR Research Unit, Queen Square 
      Multiple Sclerosis Centre; University College London Institute of Neurology 
      (D.H.M., C.A.M.W.-K., D.J.T., D.G.M., T.A.Y.), UK; Mellen Center for Multiple 
      Sclerosis Treatment and Research (R.J.F.), Cleveland Clinic, OH; Multiple 
      Sclerosis Program (J.T.P.), Baylor Institute for Immunology Research, Dallas, TX; 
      St. Vincent's University Hospital (M.H.), Elm Park, Donnybrook, Dublin, Ireland; 
      Department of Neurology (E.H.), First Faculty of Medicine, Charles University, 
      Prague, Czech Republic; Virginia Mason Medical Center (M.K.), Seattle, WA; 
      CircleScience (M.G.), Tytherington, UK; and Biogen Idec Incorporated (M.Y., R.Z., 
      V.V., K.T.D.), Weston, MA.
CN  - CONFIRM study investigators
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150213
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Fumarates)
RN  - 0 (Immunosuppressive Agents)
RN  - FO2303MNI2 (Dimethyl Fumarate)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Delayed-Action Preparations/administration & dosage
MH  - Dimethyl Fumarate
MH  - Double-Blind Method
MH  - Female
MH  - Fumarates/*administration & dosage
MH  - Humans
MH  - Immunosuppressive Agents/*administration & dosage
MH  - Internationality
MH  - *Magnetic Resonance Imaging/trends
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*diagnosis/*drug therapy
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC4371413
FIR - Fox, Robert J
IR  - Fox RJ
FIR - Phillips, J Theodore
IR  - Phillips JT
FIR - Hutchinson, Michael
IR  - Hutchinson M
FIR - Havrdova, Eva
IR  - Havrdova E
FIR - Kita, Mariko
IR  - Kita M
FIR - Wilson, Kate
IR  - Wilson K
FIR - Yang, Minhua
IR  - Yang M
FIR - Dawson, Katherine T
IR  - Dawson KT
FIR - Antel, Jack
IR  - Antel J
FIR - Ware, James
IR  - Ware J
FIR - Polman, Chris
IR  - Polman C
FIR - Kowey, Peter R
IR  - Kowey PR
FIR - Chung, Raymond
IR  - Chung R
FIR - Bakris, George
IR  - Bakris G
FIR - Richert, John
IR  - Richert J
FIR - Seibert, Burt
IR  - Seibert B
FIR - Brandes, David
IR  - Brandes D
FIR - Brassat, David
IR  - Brassat D
FIR - Cohen, Bruce
IR  - Cohen B
FIR - Diem, Ricarda
IR  - Diem R
FIR - Goldman, Myla
IR  - Goldman M
FIR - Herndon, Robert
IR  - Herndon R
FIR - Miller, Aaron
IR  - Miller A
FIR - Tumani, Hayrettin
IR  - Tumani H
FIR - Alfaro-Vidal, Teresa
IR  - Alfaro-Vidal T
FIR - Crespo, Carolina
IR  - Crespo C
FIR - Foster, Jo
IR  - Foster J
FIR - Hunter, Kelvin
IR  - Hunter K
FIR - Garcia-Gomez, Almudena
IR  - Garcia-Gomez A
FIR - MacManus, David
IR  - MacManus D
FIR - Miller, David
IR  - Miller D
FIR - Santana, Virginia
IR  - Santana V
FIR - Tozer, Dan
IR  - Tozer D
FIR - Wheeler-Kingshott, Claudia
IR  - Wheeler-Kingshott C
FIR - Yousry, Tarek
IR  - Yousry T
FIR - Kneebone, Christopher
IR  - Kneebone C
FIR - Fedulau, Aliaksandr
IR  - Fedulau A
FIR - Likhachev, Sergey
IR  - Likhachev S
FIR - Mikhailova, Elena
IR  - Mikhailova E
FIR - Naumova, Halina
IR  - Naumova H
FIR - Decoo, Danny
IR  - Decoo D
FIR - Gaer, Luc Vande
IR  - Gaer LV
FIR - Sindic, Christian
IR  - Sindic C
FIR - Grgic, Sanja
IR  - Grgic S
FIR - Sinanovic, Osman
IR  - Sinanovic O
FIR - Suljic, Enra Mehmedika
IR  - Suljic EM
FIR - Deleva, Nadezhda
IR  - Deleva N
FIR - Georgiev, Dimitar
IR  - Georgiev D
FIR - Haralanov, Lyubomir
IR  - Haralanov L
FIR - Ivanova, Sonyia
IR  - Ivanova S
FIR - Manchev, Ivan
IR  - Manchev I
FIR - Minchev, Dimitar
IR  - Minchev D
FIR - Stamenova, Paraskeva
IR  - Stamenova P
FIR - Tournev, Ivailo
IR  - Tournev I
FIR - Vacheva, Elena
IR  - Vacheva E
FIR - Zahariev, Zahari
IR  - Zahariev Z
FIR - Bar-Or, Amit
IR  - Bar-Or A
FIR - Blevins, Gregg
IR  - Blevins G
FIR - Kremenchutzky, Marcelo
IR  - Kremenchutzky M
FIR - Veloso, Felix
IR  - Veloso F
FIR - Witt, Norbert
IR  - Witt N
FIR - Vargas Howell, Roberto
IR  - Vargas Howell R
FIR - Vindas, Alexander Parajeles
IR  - Vindas AP
FIR - Habek, Mario
IR  - Habek M
FIR - Rudez, Josip
IR  - Rudez J
FIR - Soldo-Butkovic, Silva
IR  - Soldo-Butkovic S
FIR - Vurdelja, Ranka Baraba
IR  - Vurdelja RB
FIR - Dolezil, David
IR  - Dolezil D
FIR - Havrdova, Eva
IR  - Havrdova E
FIR - Nova'k, Jiri
IR  - Nova'k J
FIR - Vaclavik, Daniel
IR  - Vaclavik D
FIR - Antsov, Katrin
IR  - Antsov K
FIR - Gross-Paju, Katrin
IR  - Gross-Paju K
FIR - Haldre, Sulev
IR  - Haldre S
FIR - Palu, Alla
IR  - Palu A
FIR - Toomsoo, Toomas
IR  - Toomsoo T
FIR - Al Khedr, Abdullatif
IR  - Al Khedr A
FIR - Camu, William
IR  - Camu W
FIR - Debouverie, Marc
IR  - Debouverie M
FIR - Defer, Gilles
IR  - Defer G
FIR - De Seze, Jerome
IR  - De Seze J
FIR - Labauge, Pierre
IR  - Labauge P
FIR - Moreau, Thibault
IR  - Moreau T
FIR - Pelletier, Jean
IR  - Pelletier J
FIR - Rumbach, Lucien
IR  - Rumbach L
FIR - Daskalovska, Vera
IR  - Daskalovska V
FIR - Angnstwurm, Klemens
IR  - Angnstwurm K
FIR - Benes, Heike
IR  - Benes H
FIR - Berthele, Achim
IR  - Berthele A
FIR - Boldt, Hans-Jurgen
IR  - Boldt HJ
FIR - Christopher, Angelika
IR  - Christopher A
FIR - Derfuss, Tobias
IR  - Derfuss T
FIR - Eisensehr, Ilonka
IR  - Eisensehr I
FIR - Emrich, Peter
IR  - Emrich P
FIR - Feneberg, Wolfgang
IR  - Feneberg W
FIR - Hoffmann, Frank
IR  - Hoffmann F
FIR - Hohlfeld, Reinhard
IR  - Hohlfeld R
FIR - Huntemann, Reinhard
IR  - Huntemann R
FIR - Kallmann, Boris-Alexander
IR  - Kallmann BA
FIR - Kieseier, Bernd
IR  - Kieseier B
FIR - Landefeld, Harald
IR  - Landefeld H
FIR - Luer, Wilfried
IR  - Luer W
FIR - Masri, Sabine
IR  - Masri S
FIR - Nelles, Gereon
IR  - Nelles G
FIR - Oschmann, Patrick
IR  - Oschmann P
FIR - Paschen, Christine
IR  - Paschen C
FIR - Reifschneider, Gerd
IR  - Reifschneider G
FIR - Sailer, Michael
IR  - Sailer M
FIR - Schimrigk, Sebastian
IR  - Schimrigk S
FIR - Spiegel-Meixensberger, Mechthild
IR  - Spiegel-Meixensberger M
FIR - Storch-Hagenlocher, Brigitte
IR  - Storch-Hagenlocher B
FIR - Tackenberg, Bjorn
IR  - Tackenberg B
FIR - Tiel-Wilck, Klaus
IR  - Tiel-Wilck K
FIR - Karageorgiou, Clementine
IR  - Karageorgiou C
FIR - Papathanasopoulos, Panagiotis
IR  - Papathanasopoulos P
FIR - Thomaides, Thomas
IR  - Thomaides T
FIR - Vlaikidis, Nicholas
IR  - Vlaikidis N
FIR - Arjundas, Deepak
IR  - Arjundas D
FIR - Behari, Madhuri
IR  - Behari M
FIR - Ghosh, Amitabha
IR  - Ghosh A
FIR - Ghosh, Pahari
IR  - Ghosh P
FIR - Ichaporia, Nasli Rustom
IR  - Ichaporia NR
FIR - Khurana, Dheeraj
IR  - Khurana D
FIR - Kulkarni, Rahul Vitthal
IR  - Kulkarni RV
FIR - Kumar, Suresh
IR  - Kumar S
FIR - Mehndiratta, Man Mohan
IR  - Mehndiratta MM
FIR - Mehta, Neeta Abhay
IR  - Mehta NA
FIR - Misra, Usha Kant
IR  - Misra UK
FIR - Mukherji, Joy Dev
IR  - Mukherji JD
FIR - Nellikunja, Shankara
IR  - Nellikunja S
FIR - Salem, Abdul
IR  - Salem A
FIR - Sethi, Prahlad Kumar
IR  - Sethi PK
FIR - Shah, Shalin Dipinkumar
IR  - Shah SD
FIR - Singh, Gagandeep
IR  - Singh G
FIR - Singh, Maneesh Kumar
IR  - Singh MK
FIR - Singh, Yash Pal
IR  - Singh YP
FIR - Srinivasa, Rangasetty
IR  - Srinivasa R
FIR - Vijayan, Krishnan
IR  - Vijayan K
FIR - Hutchinson, Michael
IR  - Hutchinson M
FIR - Sweeney, Bernard
IR  - Sweeney B
FIR - Gilad, Ronit
IR  - Gilad R
FIR - Shahien, Radi
IR  - Shahien R
FIR - Paegle, Anita
IR  - Paegle A
FIR - Delgado, Cesar
IR  - Delgado C
FIR - Escamilla, Juan
IR  - Escamilla J
FIR - Estanol, Bruno
IR  - Estanol B
FIR - Lopez, Minerva
IR  - Lopez M
FIR - Macias, Miguel Angel
IR  - Macias MA
FIR - Punzo, Guillermo
IR  - Punzo G
FIR - Quinones, Sandra
IR  - Quinones S
FIR - Renteria, Mariela
IR  - Renteria M
FIR - Santos, Jose
IR  - Santos J
FIR - Gavriliuc, Mihail
IR  - Gavriliuc M
FIR - Groppa, Stanislav
IR  - Groppa S
FIR - Odainic, Olesea
IR  - Odainic O
FIR - Timmings, Paul
IR  - Timmings P
FIR - Czlonkowska, Anna
IR  - Czlonkowska A
FIR - Dorobek, Malgorzata
IR  - Dorobek M
FIR - Drozdowski, Wieslaw
IR  - Drozdowski W
FIR - Fryze, Waldemar
IR  - Fryze W
FIR - Hertmanowska, Hanka
IR  - Hertmanowska H
FIR - Kaminska, Anna
IR  - Kaminska A
FIR - Kapelusiak-Pielok, Magdalena
IR  - Kapelusiak-Pielok M
FIR - Kleczkowska, Magdalena
IR  - Kleczkowska M
FIR - Kochanowicz, Jan
IR  - Kochanowicz J
FIR - Losy, Jacek
IR  - Losy J
FIR - Nowacki, Przemyslaw
IR  - Nowacki P
FIR - Nyka, Walenty
IR  - Nyka W
FIR - Pierzchala, Krystyna
IR  - Pierzchala K
FIR - Podemski, Ryszard
IR  - Podemski R
FIR - Potemkowski, Andrzej
IR  - Potemkowski A
FIR - Selmaj, Krzysztof
IR  - Selmaj K
FIR - Stelmasiak, Zbigniew
IR  - Stelmasiak Z
FIR - Szczudlik, Andrzej
IR  - Szczudlik A
FIR - Tutaj, Andrzej
IR  - Tutaj A
FIR - Wajgt, Andrzej
IR  - Wajgt A
FIR - Zielinski, Tomasz
IR  - Zielinski T
FIR - Balasa, Rodica
IR  - Balasa R
FIR - Ionescu-Dimancea, Valentin
IR  - Ionescu-Dimancea V
FIR - Mihancea, Petru
IR  - Mihancea P
FIR - Popescu, Cristian
IR  - Popescu C
FIR - Protosevici, Liviu Codrut
IR  - Protosevici LC
FIR - Miletic Drakulic, Svetlana
IR  - Miletic Drakulic S
FIR - Nadj, Congor
IR  - Nadj C
FIR - Raicevic, Ranko
IR  - Raicevic R
FIR - Vojinovic, Slobodan
IR  - Vojinovic S
FIR - Kahancova, Edita
IR  - Kahancova E
FIR - Kurca, Egon
IR  - Kurca E
FIR - Lisy, L'ubomir
IR  - Lisy L
FIR - Turcani, Peter
IR  - Turcani P
FIR - Arroyo, Rafael
IR  - Arroyo R
FIR - Fernandez, Oscar
IR  - Fernandez O
FIR - Guijarro, Cristina
IR  - Guijarro C
FIR - Izquierdo, Guillermo
IR  - Izquierdo G
FIR - Lopez, Fernando Sanchez
IR  - Lopez FS
FIR - Montalban, Xavier
IR  - Montalban X
FIR - Oreja-Guevara, Celia
IR  - Oreja-Guevara C
FIR - Prieto, Jose Maria
IR  - Prieto JM
FIR - Buchakchyys'ka, Nataliya
IR  - Buchakchyys'ka N
FIR - Chmyr, Galyna
IR  - Chmyr G
FIR - Goloborodko, Alla
IR  - Goloborodko A
FIR - Kobys, Tetyana
IR  - Kobys T
FIR - Kushnir, Grygory
IR  - Kushnir G
FIR - Lebedynets, Volodymyr
IR  - Lebedynets V
FIR - Lytvynenko, Nataliya
IR  - Lytvynenko N
FIR - Moskovko, Sergii
IR  - Moskovko S
FIR - Nehrych, Tetyana
IR  - Nehrych T
FIR - Palamar, Borys
IR  - Palamar B
FIR - Pasyura, Igor
IR  - Pasyura I
FIR - Ryabichenko, Tatyana
IR  - Ryabichenko T
FIR - Voloshina, Nataliya
IR  - Voloshina N
FIR - Apperson, Michelle
IR  - Apperson M
FIR - Applebee, Angela
IR  - Applebee A
FIR - Asher, Stephen
IR  - Asher S
FIR - Ayala, Ricardo
IR  - Ayala R
FIR - Ayres, Donald
IR  - Ayres D
FIR - Azizi, S Ausim
IR  - Azizi SA
FIR - Baker, Matthew
IR  - Baker M
FIR - Bauer, Brendan
IR  - Bauer B
FIR - Bomprezzi, Roberto
IR  - Bomprezzi R
FIR - Buckler, Richard
IR  - Buckler R
FIR - Carlini, Walter
IR  - Carlini W
FIR - Chinea, Angel
IR  - Chinea A
FIR - Cohan, Stanley
IR  - Cohan S
FIR - Crowell, Giles
IR  - Crowell G
FIR - Edwards, Keith
IR  - Edwards K
FIR - Eubank, Geoffery
IR  - Eubank G
FIR - Felton, Warren 3rd
IR  - Felton W 3rd
FIR - Fodor, Patricia
IR  - Fodor P
FIR - Foley, John
IR  - Foley J
FIR - Ford, Corey
IR  - Ford C
FIR - Fox, Edward
IR  - Fox E
FIR - Fox, Robert
IR  - Fox R
FIR - Forester, Mary
IR  - Forester M
FIR - Freedman, Steven
IR  - Freedman S
FIR - Garmany, George Jr
IR  - Garmany G Jr
FIR - Gazda, Suzanne
IR  - Gazda S
FIR - Giang, Daniel
IR  - Giang D
FIR - Glaun, Braeme
IR  - Glaun B
FIR - Gold, Scott
IR  - Gold S
FIR - Gottesman, Malcolm
IR  - Gottesman M
FIR - Gudesblatt, Mark
IR  - Gudesblatt M
FIR - Herbert, Joseph
IR  - Herbert J
FIR - Herskowitz, Allan
IR  - Herskowitz A
FIR - Honeycutt, William
IR  - Honeycutt W
FIR - Huddlestone, John
IR  - Huddlestone J
FIR - Hull, Richard
IR  - Hull R
FIR - Hunter, Samuel
IR  - Hunter S
FIR - Hutton, George
IR  - Hutton G
FIR - Jacobs, Dina
IR  - Jacobs D
FIR - Janicki, Mark
IR  - Janicki M
FIR - Khatri, Bhupendra
IR  - Khatri B
FIR - Kinkel, Revere Philip
IR  - Kinkel RP
FIR - Kita, Mariko
IR  - Kita M
FIR - Krolczyk, Stanley
IR  - Krolczyk S
FIR - Krupp, Lauren
IR  - Krupp L
FIR - LaGanke, Christopher
IR  - LaGanke C
FIR - Levin, Michael
IR  - Levin M
FIR - Licht, Jonathan
IR  - Licht J
FIR - Luzzio, Christopher
IR  - Luzzio C
FIR - Lynch, Sharon
IR  - Lynch S
FIR - Mattson, David
IR  - Mattson D
FIR - Mikol, Daniel
IR  - Mikol D
FIR - Miller, Tamara
IR  - Miller T
FIR - Minagar, Alireza
IR  - Minagar A
FIR - Mitchell, Galen
IR  - Mitchell G
FIR - Moses, Harold Jr
IR  - Moses H Jr
FIR - Negroski, Donald
IR  - Negroski D
FIR - Newman, Stephen
IR  - Newman S
FIR - Pardo, Gabriel
IR  - Pardo G
FIR - Patel, Malti
IR  - Patel M
FIR - Perel, Allan
IR  - Perel A
FIR - Phillips, Joseph Jr
IR  - Phillips J Jr
FIR - Picone, Mary Ann
IR  - Picone MA
FIR - Rammohan, Kottil
IR  - Rammohan K
FIR - Rao, T Hemanth
IR  - Rao TH
FIR - Rinker, John 2nd
IR  - Rinker J 2nd
FIR - Sadiq, Saud
IR  - Sadiq S
FIR - Schaeffer, John
IR  - Schaeffer J
FIR - Sheremata, William
IR  - Sheremata W
FIR - Shin, Robert
IR  - Shin R
FIR - Shubin, Richard
IR  - Shubin R
FIR - Silverman, Stuart
IR  - Silverman S
FIR - Smith, Robert
IR  - Smith R
FIR - Stein, Lee
IR  - Stein L
FIR - Stein, Michael
IR  - Stein M
FIR - Steiner, David
IR  - Steiner D
FIR - Steingo, Brian
IR  - Steingo B
FIR - Sullivan, Herman
IR  - Sullivan H
FIR - Sunter, William Jr
IR  - Sunter W Jr
FIR - Vaishnav, Anand
IR  - Vaishnav A
FIR - Vasquez, Alberto
IR  - Vasquez A
FIR - Voci, James
IR  - Voci J
FIR - Warach, Jonathan
IR  - Warach J
FIR - Weinstock-Guttman, Bianca
IR  - Weinstock-Guttman B
FIR - Williams, Mitzi
IR  - Williams M
FIR - Wray, Sibyl
IR  - Wray S
EDAT- 2015/02/15 06:00
MHDA- 2015/06/16 06:00
PMCR- 2015/03/17
CRDT- 2015/02/15 06:00
PHST- 2015/02/15 06:00 [entrez]
PHST- 2015/02/15 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
PHST- 2015/03/17 00:00 [pmc-release]
AID - WNL.0000000000001360 [pii]
AID - NEUROLOGY2013532259 [pii]
AID - 10.1212/WNL.0000000000001360 [doi]
PST - ppublish
SO  - Neurology. 2015 Mar 17;84(11):1145-52. doi: 10.1212/WNL.0000000000001360. Epub 
      2015 Feb 13.