PMID- 2568150
OWN - NLM
STAT- MEDLINE
DCOM- 19890814
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 488
IP  - 1-2
DP  - 1989 May 29
TI  - Modulation of central nervous system actions of corticotropin-releasing factor by 
      dynorphin-related peptides.
PG  - 233-40
AB  - Corticotropin-releasing factor (CRF) and dynorphin-related peptides are 
      co-localized within a subset of hypothalamic neurons suggesting the possibility 
      of their co-release. Therefore, studies were performed in conscious unrestrained 
      rats to examine whether dynorphin-related peptides modify the central nervous 
      system (CNS) actions of CRF on sympathetic nervous activity and cardiovascular 
      function. Intracerebroventricular (i.c.v.) administration of dynorphin A1-8 (0.1 
      and 1.0 nmol) did not alter arterial pressure (AP) or heart rate (HR). I.c.v. 
      injection of dynorphin A1-13 (0.1, 0.3 and 1.0 nmol) produced transient 
      elevations of HR but did not significantly affect AP. I.c.v. administration of 
      dynorphin A1-17 (0.1, 0.3 and 1.0 nmol) elicited delayed (10-15 min) and 
      transient elevations of AP and HR. CRF (0.15 nmol, i.c.v.) produced immediate and 
      sustained elevations of AP, HR and plasma catecholamine levels. Upon simultaneous 
      administration, 0.1 nmol of dynorphin A1-17, but not 0.1 nmol of dynorphin A1-8 
      or dynorphin A1-13, markedly attenuated CRF-induced elevations of AP, HR, and 
      plasma catecholamine levels. The results suggest that selected dynorphin-related 
      peptides may modify the CNS actions of CRF.
FAU - Overton, J M
AU  - Overton JM
AD  - Department of Pharmacology, College of Medicine, University of Arizona, Tucson 
      85724.
FAU - Fisher, L A
AU  - Fisher LA
LA  - eng
GR  - HL-07839/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 74913-18-1 (Dynorphins)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Brain/drug effects/*physiology
MH  - Cardiovascular System/*drug effects
MH  - Corticotropin-Releasing Hormone/*pharmacology
MH  - Drug Interactions
MH  - Dynorphins/*pharmacology
MH  - Heart Rate/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sympathetic Nervous System/*drug effects
EDAT- 1989/05/29 00:00
MHDA- 1989/05/29 00:01
CRDT- 1989/05/29 00:00
PHST- 1989/05/29 00:00 [pubmed]
PHST- 1989/05/29 00:01 [medline]
PHST- 1989/05/29 00:00 [entrez]
AID - 0006-8993(89)90713-0 [pii]
AID - 10.1016/0006-8993(89)90713-0 [doi]
PST - ppublish
SO  - Brain Res. 1989 May 29;488(1-2):233-40. doi: 10.1016/0006-8993(89)90713-0.