PMID- 25681548
OWN - NLM
STAT- MEDLINE
DCOM- 20160115
LR  - 20150330
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1605
DP  - 2015 Apr 24
TI  - Changes in the BDNF-immunopositive cell population of neocortical layers I and 
      II/III after focal cerebral ischemia in rats.
PG  - 76-82
LID - S0006-8993(15)00091-8 [pii]
LID - 10.1016/j.brainres.2015.02.007 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family 
      and is widely distributed in the central nervous system, including the cerebral 
      cortex. BDNF plays an important role in normal neural development, survival of 
      existing neurons, and activity-dependent neuroplasticity. BDNF can also be 
      neuroprotective and evoke neurogenesis in certain pathological conditions, such 
      as cerebral ischemia. Neocortical layer I is an important region that can 
      integrate feedforward and feedback information from other cortical areas and 
      subcortical regions. In addition, it has recently been proposed as a possible 
      source of neuronal progenitor cells after ischemia. Therefore, we investigated 
      changes in the BDNF-immunoreactive cell population of neocortical layers I and 
      II/III after middle cerebral artery occlusion (MCAO)-induced cerebral ischemia in 
      rats. In unaffected condition, the number of BDNF(+) cells in layer I was 
      significantly less than in layer II/III in the cingulate cortex and in the motor 
      and sensory areas. The increase in the number of BDNF(+) cells in layer I 8 days 
      after MCAO was more remarkable than layer II/III, in all regions except the area 
      of cingulate cortex farthest from the infarct core. Only BDNF(+)-Ox-42(+) cells 
      showed a tendency to increase consistently toward the infarct core in both layers 
      I and II/III, implying a major source of BDNF for response to ischemic injury. 
      The present study suggests that some beneficial effects during recovery from 
      ischemic injury, such as increased supportive microglia/macrophages, occur owing 
      to a sensitive response of BDNF in layer I.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Choi, Yongwon
AU  - Choi Y
AD  - Department of Rehabilitation Science, Inje University, Gimhae 621-749, Republic 
      of Korea; U-Healthcare & Anti-aging Research Center, Inje University, Gimhae 
      621-749, Republic of Korea.
FAU - Kang, Sung Goo
AU  - Kang SG
AD  - Department of Biological Sciences, Institute of Basic Science, Inje University, 
      Gimhae 621-749, Republic of Korea.
FAU - Kam, Kyung-Yoon
AU  - Kam KY
AD  - Department of Occupational Therapy, Inje University, Gimhae 621-749, Republic of 
      Korea; U-Healthcare & Anti-aging Research Center, Inje University, Gimhae 
      621-749, Republic of Korea. Electronic address: kamlapa@inje.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150212
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/*metabolism/pathology
MH  - Disease Models, Animal
MH  - Male
MH  - Neocortex/*metabolism/pathology
MH  - Neurons/*metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - BDNF
OT  - Ischemia
OT  - Macrophage
OT  - Microglia
OT  - Neocortical layer I
EDAT- 2015/02/15 06:00
MHDA- 2016/01/16 06:00
CRDT- 2015/02/15 06:00
PHST- 2014/08/25 00:00 [received]
PHST- 2015/02/03 00:00 [revised]
PHST- 2015/02/04 00:00 [accepted]
PHST- 2015/02/15 06:00 [entrez]
PHST- 2015/02/15 06:00 [pubmed]
PHST- 2016/01/16 06:00 [medline]
AID - S0006-8993(15)00091-8 [pii]
AID - 10.1016/j.brainres.2015.02.007 [doi]
PST - ppublish
SO  - Brain Res. 2015 Apr 24;1605:76-82. doi: 10.1016/j.brainres.2015.02.007. Epub 2015 
      Feb 12.