PMID- 25681742
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20150324
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 50
IP  - 2
DP  - 2015 Jun
TI  - Identification of the Atlantic cod L-amino acid oxidase and its alterations 
      following bacterial exposure.
PG  - 116-20
LID - S0145-305X(15)00030-0 [pii]
LID - 10.1016/j.dci.2015.02.007 [doi]
AB  - Antibacterial factors that are present in epidermal mucus of fish have a 
      potential role in the first line of host defence to bacterial pathogens. This 
      study reports the identification of L-amino acid oxidase (LAO) in Atlantic cod 
      (GmLao) and the changes in the molecule following bacterial exposure. The gmlao 
      transcripts and LAO activity were present on both the body surface and in the 
      internal organs of the fish. Relative mRNA level of gmlao increased significantly 
      in the gills, the spleen and the head kidney (up to 8-fold) of fish that were 
      challenged with the pathogen Vibrio anguillarum. The gmlao expression in skin was 
      4-fold higher in challenged fish. Our data indicate that LAO may be an important 
      effector of antibacterial defence in Atlantic cod.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Kitani, Yoichiro
AU  - Kitani Y
AD  - Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodo, 
      Norway. Electronic address: yki@uin.no.
FAU - Fernandes, Jorge M O
AU  - Fernandes JM
AD  - Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodo, 
      Norway.
FAU - Kiron, Viswanath
AU  - Kiron V
AD  - Faculty of Biosciences and Aquaculture, University of Nordland, 8049 Bodo, 
      Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150211
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Fish Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 1.4.3.2 (L-Amino Acid Oxidase)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*metabolism
MH  - Fish Diseases/*immunology/microbiology
MH  - Fish Proteins/genetics/metabolism
MH  - Gadus morhua/*immunology/microbiology
MH  - Gene Expression Profiling
MH  - Gills/metabolism
MH  - Head Kidney/metabolism
MH  - L-Amino Acid Oxidase/genetics/*metabolism
MH  - RNA, Messenger/genetics
MH  - Skin/metabolism
MH  - Spleen/metabolism
MH  - Vibrio/*immunology
OTO - NOTNLM
OT  - Antimicrobial protein (AMP)
OT  - Atlantic cod Gadus morhua
OT  - Bacterial exposure
OT  - Tissue distribution
OT  - Vibrio anguillarum
OT  - l-amino acid oxidase
EDAT- 2015/02/15 06:00
MHDA- 2016/02/03 06:00
CRDT- 2015/02/15 06:00
PHST- 2014/11/30 00:00 [received]
PHST- 2015/02/08 00:00 [revised]
PHST- 2015/02/08 00:00 [accepted]
PHST- 2015/02/15 06:00 [entrez]
PHST- 2015/02/15 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
AID - S0145-305X(15)00030-0 [pii]
AID - 10.1016/j.dci.2015.02.007 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2015 Jun;50(2):116-20. doi: 10.1016/j.dci.2015.02.007. Epub 
      2015 Feb 11.