PMID- 25682252
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20150403
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 138
DP  - 2015 Apr
TI  - Associations of organochlorine pesticides and polychlorinated biphenyls with 
      total, cardiovascular, and cancer mortality in elders with differing fat mass.
PG  - 1-7
LID - S0013-9351(15)00024-9 [pii]
LID - 10.1016/j.envres.2015.01.021 [doi]
AB  - BACKGROUND: We investigated if certain persistent organic pollutants (POPs), 
      namely polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides, 
      predicted total, cardiovascular disease (CVD), and cancer mortality among the 
      elderly, with the hypothesis that associations differ by the amount of fat mass. 
      METHODS: We studied serum concentrations of 11 PCBs in 633 elders (age>/=70 years) 
      and of 5 OC pesticides in 675 elders within the National Health and Nutrition 
      Examination Survey (NHANES) 1999-2004. Mean follow-up was 4.1-years. RESULTS: 
      Neither PCBs nor OC pesticides were associated with total mortality when fat mass 
      was not considered in analyses. However, associations of PCBs and OC pesticides 
      with total mortality depended on fat mass (Pinteraction<0.01 and 0.06, 
      respectively). PCBs associated inversely with total mortality for high fat mass, 
      but not for lower fat mass. On the contrary, OC pesticides associated positively 
      with total mortality for low fat mass and this association weakened at higher fat 
      mass. The interaction was also observed with CVD mortality. In elders with low 
      fat mass, higher PCBs associated with 2-3 fold higher risk of CVD mortality, 
      while this association was absent in elders with more fat mass 
      (Pinteraction=0.03). The positive association between OC pesticides and CVD 
      mortality was also observed only among elderly with low fat mass 
      (Pinteraction=0.03). CONCLUSIONS: The possibility of interaction between POPs and 
      the amount of fat mass on risk of mortality from chronic diseases is clinically 
      important in modern societies with an obesity epidemic and requires confirmation 
      in other studies with larger sample size.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Kim, Se-A
AU  - Kim SA
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea; Department of Biomedical Science, Kyungpook 
      National University, Daegu, Republic of Korea; BK21 Plus KNU Biomedical 
      Convergence Program, Department of Biomedical Science, Kyungpook National 
      University, Republic of Korea.
FAU - Kim, Ki-Su
AU  - Kim KS
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea.
FAU - Lee, Yu-Mi
AU  - Lee YM
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea.
FAU - Jacobs, David R
AU  - Jacobs DR
AD  - Division of Epidemiology, School of Public Health, University of Minnesota, 
      Minneapolis, MN, USA.
FAU - Lee, Duk-Hee
AU  - Lee DH
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, Daegu, Republic of Korea; Department of Biomedical Science, Kyungpook 
      National University, Daegu, Republic of Korea; BK21 Plus KNU Biomedical 
      Convergence Program, Department of Biomedical Science, Kyungpook National 
      University, Republic of Korea. Electronic address: lee_dh@knu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150213
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adiposity
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiovascular Diseases/chemically induced/*mortality
MH  - *Environmental Exposure
MH  - Environmental Pollutants/blood
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Male
MH  - Neoplasms/chemically induced/*mortality
MH  - Nutrition Surveys
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Proportional Hazards Models
MH  - United States/epidemiology
OTO - NOTNLM
OT  - Cancer mortality
OT  - Cardiovascular mortality
OT  - Fat mass
OT  - Obesity
OT  - Organochlorine pesticides
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
EDAT- 2015/02/16 06:00
MHDA- 2015/06/16 06:00
CRDT- 2015/02/16 06:00
PHST- 2014/09/05 00:00 [received]
PHST- 2015/01/26 00:00 [revised]
PHST- 2015/01/28 00:00 [accepted]
PHST- 2015/02/16 06:00 [entrez]
PHST- 2015/02/16 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - S0013-9351(15)00024-9 [pii]
AID - 10.1016/j.envres.2015.01.021 [doi]
PST - ppublish
SO  - Environ Res. 2015 Apr;138:1-7. doi: 10.1016/j.envres.2015.01.021. Epub 2015 Feb 
      13.