PMID- 25682974
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20220410
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 37
IP  - 4
DP  - 2015 May
TI  - Association between red blood cell distribution and renal function in patients 
      with untreated type 2 diabetes mellitus.
PG  - 659-63
LID - 10.3109/0886022X.2015.1010938 [doi]
AB  - We assessed whether red cell distribution width (RDW) is associated with 
      microalbuminuria (MAU) in a group of 320 patients with newly diagnosed type 2 
      diabetes mellitus (T2DM), recruited in Zhengzhou. Patients were divided into 
      normal group and MAU group. Compared with the normal group, the patients with MAU 
      had higher red blood cell count (p = 0.005) and RDW (p < 0.001). The multiple 
      logistic regression indicated that RDW (OR = 3.89, 95% CI: 1.98-7.66, p < 0.001) 
      was an independent risk factor of MAU in newly diagnosed T2DM. Other factors 
      include smoking (OR = 4.44, 95% CI: 2.90-8.72, p < 0.001), higher waist index 
      (OR = 2.17, 95% CI: 1.89-5.26, p = 0.002), FBG level (OR = 2.05, 95% CI: 
      1.21-3.84, p = 0.008) and uric acid level (OR = 2.18, 95% CI: 1.05-4.52, 
      p = 0.037). The receiver operating characteristic (ROC) curves explored the 
      relationship between MAU and RDW. The area under the curve was 0.79 (95% CI: 
      0.74-0.84; p < 0.001). Using a cut-off point of 12.8, the RDW predicted MAU in 
      the T2DM patients with a sensitivity of 71.3% and specificity of 66.9%. RDW may 
      be independently associated with MAU in patients with newly diagnosed T2DM. RDW 
      may be treated as effective predictive index in the evaluation of diabetes 
      nephropathy or diabetes-associated complications.
FAU - Zhang, Min
AU  - Zhang M
AD  - Department of Pathology, The Second Affiliated Hospital of Zhengzhou University , 
      Zhengzhou, Henan Province , China .
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Li, Che
AU  - Li C
FAU - He, Linhua
AU  - He L
LA  - eng
PT  - Journal Article
DEP - 20150216
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
SB  - IM
MH  - Albuminuria/*blood/*physiopathology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/*physiopathology
MH  - *Erythrocyte Indices
MH  - Female
MH  - Humans
MH  - Kidney/*physiopathology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - diabetes mellitus
OT  - microalbuminuria
OT  - red cell distribution width
OT  - renal function
EDAT- 2015/02/17 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/02/17 06:00
PHST- 2015/02/17 06:00 [entrez]
PHST- 2015/02/17 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - 10.3109/0886022X.2015.1010938 [doi]
PST - ppublish
SO  - Ren Fail. 2015 May;37(4):659-63. doi: 10.3109/0886022X.2015.1010938. Epub 2015 
      Feb 16.