PMID- 25683933
OWN - NLM
STAT- MEDLINE
DCOM- 20150902
LR  - 20181202
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 19
IP  - 2
DP  - 2015
TI  - Comparative analysis of MCP-1 and TF in elderly patients with acute exacerbations 
      of COPD and its clinical significance.
PG  - 215-9
LID - 8404 [pii]
AB  - OBJECTIVE: This study was conducted to investigate the variation of monocyte 
      chemoattrant protein-1 (MCP-1) and tissue factor (TF) in elderly patients with 
      acutely exacerbated chronic obstructive pulmonary disease (AECOPD) and their 
      clinical significance. PATIENTS AND METHODS: Serum specimens were obtained from 
      49 AECOPD. Patients and 30 health controls, with mean age of 76.1 +/- 10.2 and 62.8 
      +/- 6.5 years. Patients in AECOPD group were further grouped into two subgroups, 
      with high or normal procaletonin (PCT) levels. Plasma TE, MCP-1 and PCT were 
      qualified by enzyme-linked immunosorbent assay (ELISA). RESULTS: TF and MCP-1 
      were found to be higher in AECOPD patients than in health people (p < 0.01), and 
      TF was linearly and positively related to MCP-1. In the subgroups TF was 
      significantly higher in patients with higher PCT than those with normal PCT (p < 
      0.05). CONCLUSIONS: In AECOPD patients blood cells are activated to 
      hypercoagulation state, particularly when their PCT level is high. Extrinsic 
      pathway activated by TE plays important role in development of the 
      hypercoagulation state. Our results indicate that plasma TF level was positively 
      correlated to the level of MCP-1. This suggests that monitoring of plasma TF and 
      MCP-1 levels in AECOPD patients could be a very useful way to prevent and cure 
      blood hypercoagulability, cardiovascular and cerebrovascular thrombotic diseases.
FAU - Wang, Y
AU  - Wang Y
AD  - Department of Emergency, Tongren Hospital, Capital Medical University, Beijing, 
      China. ningding699@163.com.
FAU - Zheng, Y
AU  - Zheng Y
FAU - Zhai, Y-L
AU  - Zhai YL
FAU - Liu, F-Q
AU  - Liu FQ
FAU - Ding, N
AU  - Ding N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 9035-58-9 (Thromboplastin)
SB  - IM
MH  - Acute Disease
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*blood/pathology
MH  - Thromboplastin/*metabolism
EDAT- 2015/02/17 06:00
MHDA- 2015/09/04 06:00
CRDT- 2015/02/17 06:00
PHST- 2015/02/17 06:00 [entrez]
PHST- 2015/02/17 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - 8404 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2015;19(2):215-9.