PMID- 25684546
OWN - NLM
STAT- MEDLINE
DCOM- 20160720
LR  - 20190221
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 67
IP  - 4
DP  - 2015 Oct
TI  - The prognostic role of the epithelial-mesenchymal transition markers E-cadherin 
      and Slug in laryngeal squamous cell carcinoma.
PG  - 491-500
LID - 10.1111/his.12668 [doi]
AB  - AIMS: Laryngeal squamous cell carcinoma (LSCC) prognosis is definitely related to 
      lymph node metastasis. Epithelial-mesenchymal transition (EMT) allows neoplastic 
      cells to gain the plasticity and motility required for tumour progression and 
      metastasis. The aim of this study was to investigate the role of EMT in the 
      prognosis of LSCC. METHODS AND RESULTS: Immunohistochemical analysis of 
      E-cadherin, N-cadherin, Snail, Slug, ZEB1, and ZEB2 was performed in 37 
      consecutive LSCC cases. Low E-cadherin levels and high Slug levels correlated 
      with both disease recurrence (P = 0.02 and P =0.01, respectively) and shorter 
      disease-free survival (DFS) (P = 0.04 and P = 0.02, respectively). Relative 
      expression levels of CDH1, SNAI2, miR-1 and the miR-200 family were also 
      evaluated. CDH1, miR-200a and miR-200c down-regulation and SNAI2 overexpression 
      were significantly associated with disease recurrence (P = 0.03, P = 0.02, P = 
      0.04, and P = 0.04, respectively). CONCLUSIONS: EMT increases tumour recurrence 
      risk and shortens DFS in LSCC. E-cadherin and Slug immunohistochemical analysis 
      could be useful for identifying patients requiring more aggressive treatment 
      after surgery.
CI  - (c) 2015 John Wiley & Sons Ltd.
FAU - Cappellesso, Rocco
AU  - Cappellesso R
AD  - Surgical Pathology and Cytopathology Unit, Department of Medicine, University of 
      Padova, Padova, Italy.
FAU - Marioni, Gino
AU  - Marioni G
AD  - Otolaryngology Section, Department of Neurosciences, University of Padova, 
      Padova, Italy.
FAU - Crescenzi, Marika
AU  - Crescenzi M
AD  - Radiotherapy Unit, Istituto Oncologico Veneto IOV, IRCCS, Padova, Italy.
FAU - Giacomelli, Luciano
AU  - Giacomelli L
AD  - Surgical Pathology and Cytopathology Unit, Department of Medicine, University of 
      Padova, Padova, Italy.
FAU - Guzzardo, Vincenza
AU  - Guzzardo V
AD  - Surgical Pathology and Cytopathology Unit, Department of Medicine, University of 
      Padova, Padova, Italy.
FAU - Mussato, Alessio
AU  - Mussato A
AD  - Surgical Pathology and Cytopathology Unit, Department of Medicine, University of 
      Padova, Padova, Italy.
FAU - Staffieri, Alberto
AU  - Staffieri A
AD  - Otolaryngology Section, Department of Neurosciences, University of Padova, 
      Padova, Italy.
FAU - Martini, Alessandro
AU  - Martini A
AD  - Otolaryngology Section, Department of Neurosciences, University of Padova, 
      Padova, Italy.
FAU - Blandamura, Stella
AU  - Blandamura S
AD  - Surgical Pathology and Cytopathology Unit, Department of Medicine, University of 
      Padova, Padova, Italy.
FAU - Fassina, Ambrogio
AU  - Fassina A
AD  - Surgical Pathology and Cytopathology Unit, Department of Medicine, University of 
      Padova, Padova, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150331
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cadherins)
RN  - 0 (SNAI1 protein, human)
RN  - 0 (SNAI2 protein, human)
RN  - 0 (Snail Family Transcription Factors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Cadherins/analysis/*biosynthesis
MH  - Carcinoma, Squamous Cell/mortality/*pathology
MH  - Disease-Free Survival
MH  - Epithelial-Mesenchymal Transition
MH  - Female
MH  - Head and Neck Neoplasms/mortality/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/pathology
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Snail Family Transcription Factors
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Transcription Factors/analysis/*biosynthesis
OTO - NOTNLM
OT  - epithelial-mesenchymal transition
OT  - laryngeal carcinoma
OT  - neck lymph node metastasis
OT  - prognosis
EDAT- 2015/02/17 06:00
MHDA- 2016/07/21 06:00
CRDT- 2015/02/17 06:00
PHST- 2014/11/17 00:00 [received]
PHST- 2015/02/04 00:00 [accepted]
PHST- 2015/02/17 06:00 [entrez]
PHST- 2015/02/17 06:00 [pubmed]
PHST- 2016/07/21 06:00 [medline]
AID - 10.1111/his.12668 [doi]
PST - ppublish
SO  - Histopathology. 2015 Oct;67(4):491-500. doi: 10.1111/his.12668. Epub 2015 Mar 31.