PMID- 25685809
OWN - NLM
STAT- MEDLINE
DCOM- 20151106
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Effects of calcium phosphate nanocrystals on osseointegration of titanium implant 
      in irradiated bone.
PG  - 783894
LID - 10.1155/2015/783894 [doi]
LID - 783894
AB  - Radiotherapy may compromise the integration of implant and cause implant loss. 
      Implant surface modifications have the possibility of promoting cell attachment, 
      cell growth, and bone formation which ultimately enhance the osseointegration 
      process. The present study aimed to investigate the effects of calcium phosphate 
      nanocrystals on implant osseointegration in irradiated bone. Sixteen rabbits were 
      randomly assigned into control and nano-CaP groups, receiving implants with dual 
      acid-etched surface or dual acid-etched surface discretely deposited of nanoscale 
      calcium-phosphate crystals, respectively. The left leg of all the rabbits 
      received 15 Gy radiation, followed by implants placement one week after. Four 
      animals in each group were sacrificed after 4 and 12 weeks, respectively. Implant 
      stability quotient (ISQ), ratio of bone volume to total volume (BV/TV), bone 
      growth rate, and bone-to-implant contact (BIC) were evaluated. The nano-CaP group 
      showed significantly higher ISQ (week 12, P = 0.031) and bone growth rate (week 
      6, P = 0.021; week 9, P = 0.001) than that in control group. No significant 
      differences in BV/TV and BIC were found between two groups. Titanium implant 
      surface modified with CaP nanocrystals provides a potential alternative to 
      improve bone healing around implant in irradiated bone.
FAU - Li, Jun Yuan
AU  - Li JY
AD  - Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong 
      Kong.
FAU - Pow, Edmond Ho Nang
AU  - Pow EH
AD  - Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong 
      Kong.
FAU - Zheng, Li Wu
AU  - Zheng LW
AUID- ORCID: 0000-0002-7593-0208
AD  - Oral Diagnosis and Polyclinics, Faculty of Dentistry, The University of Hong 
      Kong, Hong Kong.
FAU - Ma, Li
AU  - Ma L
AUID- ORCID: 0000-0003-4305-3017
AD  - Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong 
      Kong.
FAU - Kwong, Dora Lai Wan
AU  - Kwong DL
AD  - Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University 
      of Hong Kong, Hong Kong.
FAU - Cheung, Lim Kwong
AU  - Cheung LK
AD  - Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong 
      Kong, Hong Kong.
LA  - eng
PT  - Journal Article
DEP - 20150122
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Calcium Phosphates)
RN  - 97Z1WI3NDX (calcium phosphate)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - *Calcium Phosphates/chemistry/pharmacology
MH  - *Gamma Rays
MH  - Male
MH  - Nanoparticles/*chemistry
MH  - *Osseointegration/drug effects/radiation effects
MH  - *Prostheses and Implants
MH  - Rabbits
MH  - Titanium/*chemistry
PMC - PMC4317600
EDAT- 2015/02/17 06:00
MHDA- 2015/11/07 06:00
PMCR- 2015/01/22
CRDT- 2015/02/17 06:00
PHST- 2014/07/14 00:00 [received]
PHST- 2014/10/08 00:00 [accepted]
PHST- 2015/02/17 06:00 [entrez]
PHST- 2015/02/17 06:00 [pubmed]
PHST- 2015/11/07 06:00 [medline]
PHST- 2015/01/22 00:00 [pmc-release]
AID - 10.1155/2015/783894 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:783894. doi: 10.1155/2015/783894. Epub 2015 Jan 22.