PMID- 25686647
OWN - NLM
STAT- MEDLINE
DCOM- 20160909
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 56
IP  - 10
DP  - 2015
TI  - Impact of transplant eligibility and availability of a human leukocyte 
      antigen-identical matched related donor on outcome of older patients with acute 
      lymphoblastic leukemia.
PG  - 2812-8
LID - 10.3109/10428194.2015.1014365 [doi]
AB  - The role of allogeneic hematopoietic cell transplant (allo-HCT) in elderly 
      patients with acute lymphoblastic leukemia (ALL) is unclear. We conducted a 
      prospective study including 110 homogeneously treated patients with ALL aged 
      50-70 years. Their outcomes were analyzed by intention-to-treat on a 
      donor-versus-no donor basis. Fifty-five patients (50%) underwent human leukocyte 
      antigen (HLA) typing and were considered potential allo-HCT candidates, although 
      only 25 (23%) eventually received an allo-HCT. Among potential allo-HCT 
      candidates, patients with (n = 28) and without (n = 27) an HLA-identical sibling 
      showed similar leukemia-free survival, overall survival (OS) and relapse risk, 
      and the only variable associated with a better outcome was achievement of first 
      complete remission (CR1) after induction therapy. Among the 25 patients who 
      actually received an allo-HCT, the 4-year non-relapse mortality and OS were 42% 
      (95% confidence interval 31-53%) and 37% (95% confidence interval 27-47%), 
      respectively. In conclusion, having an HLA-identical sibling donor was not 
      associated with a better outcome in patients with ALL aged 50-70 years.
FAU - Barba, Pere
AU  - Barba P
AD  - a Department of Hematology , Hospital Universitari Vall d'Hebron-Universitat 
      Autonoma de Barcelona , Barcelona , Spain.
FAU - Martino, Rodrigo
AU  - Martino R
AD  - b Department of Hematology , Hospital de la Santa Creu i Sant Pau , Barcelona , 
      Spain.
FAU - Martinez-Cuadron, David
AU  - Martinez-Cuadron D
AD  - c Department of Hematology , Hospital Universitario La Fe , Valencia , Spain.
FAU - Olga, Garcia
AU  - Olga G
AD  - d Department of Hematology , ICO-Hospital Germans Trias i Pujol, Jose Carreras 
      Research Institute , Badalona , Spain.
FAU - Esquirol, Albert
AU  - Esquirol A
AD  - b Department of Hematology , Hospital de la Santa Creu i Sant Pau , Barcelona , 
      Spain.
FAU - Gil-Cortes, Cristina
AU  - Gil-Cortes C
AD  - e Department of Hematology , Hospital General , Alicante , Spain.
FAU - Gonzalez, Jose
AU  - Gonzalez J
AD  - f Department of Hematology , Hospital Virgen del Rocio , Sevilla , Spain.
FAU - Fernandez-Aviles, Francesc
AU  - Fernandez-Aviles F
AD  - g Department of Hematology , Hospital Clinic , Barcelona , Spain.
FAU - Valcarcel, David
AU  - Valcarcel D
AD  - a Department of Hematology , Hospital Universitari Vall d'Hebron-Universitat 
      Autonoma de Barcelona , Barcelona , Spain.
FAU - Guardia, Ramon
AU  - Guardia R
AD  - h Department of Hematology , Hospital Josep Trueta , Girona , Spain.
FAU - Duarte, Rafael F
AU  - Duarte RF
AD  - i Department of Hematology , Hospital Duran i Reynals, Hospitalet de Llobregat , 
      Spain.
FAU - Hernandez-Rivas, Jesus Maria
AU  - Hernandez-Rivas JM
AD  - j Department of Hematology , IBSAL, IBMCC, Centro de Investigacion del Cancer, 
      Universidad de Salamanca-CSIC and Hospital Universitario Salamanca , Salamanca , 
      Spain.
FAU - Abella, Eugenia
AU  - Abella E
AD  - k Department of Hematology , Hospital del Mar , Barcelona , Spain ; for the 
      Programa Espanol de Tratamientos en Hematologia (PETHEMA) group.
FAU - Montesinos, Pau
AU  - Montesinos P
AD  - c Department of Hematology , Hospital Universitario La Fe , Valencia , Spain.
FAU - Ribera, Josep Maria
AU  - Ribera JM
AD  - d Department of Hematology , ICO-Hospital Germans Trias i Pujol, Jose Carreras 
      Research Institute , Badalona , Spain.
LA  - eng
PT  - Journal Article
DEP - 20150306
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Leuk Lymphoma. 2015;56(10):2753-4. PMID: 25721757
MH  - Age Factors
MH  - Aged
MH  - Combined Modality Therapy
MH  - Female
MH  - *HLA Antigens/genetics/immunology
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects/methods
MH  - *Histocompatibility
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/mortality/*therapy
MH  - Recurrence
MH  - Retreatment
MH  - Risk Factors
MH  - Siblings
MH  - *Tissue Donors
MH  - Transplantation, Homologous
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Allogeneic transplant
OT  - HCT
OT  - RIC
OT  - acute lymphoblastic leukemia
EDAT- 2015/02/18 06:00
MHDA- 2016/09/10 06:00
CRDT- 2015/02/18 06:00
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2016/09/10 06:00 [medline]
AID - 10.3109/10428194.2015.1014365 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2015;56(10):2812-8. doi: 10.3109/10428194.2015.1014365. Epub 2015 
      Mar 6.